{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:05:55Z","timestamp":1779696355020,"version":"3.53.1"},"reference-count":21,"publisher":"Scientific Scholar","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"\n Purpose:<\/jats:title>\n The primary objective was to establish the reference value of gallbladder ejection fraction (GBEF) using a fatty meal-based hepatobiliary scintigraphy protocol tailored to the Indian population. In addition, the study assessed variations in GBEF across different time points and examined potential differences based on gender and age.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This prospective study was conducted from January 2023 to January 2024. Hepatobiliary scintigraphy was performed on healthy individuals aged \u226518 years following a 4-h fasting period. Static images were acquired before and after ingesting a standard fatty meal. The premeal image displaying the highest gallbladder activity concentration and minimal liver activity was selected as the reference premeal image. GBEF was calculated using decay and background-corrected counts from the reference premeal and postmeal images. Statistical analyses included independent sample\n t<\/jats:italic>\n -tests to evaluate gender differences, Pearson\u2019s correlation to assess relationships between age and GBEF, and repeated measures ANOVA with Bonferroni correction to compare GBEF across different time points. The reference value of GBEF was determined based on the 5\n th<\/jats:sup>\n percentile value at 60 min postmeal ingestion.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Twenty-three consecutive healthy individuals (13 females and 10 males) with a mean age of 42 \u00b1 12 years (median: 39 years; range: 23\u201362 years) participated in the study. The mean GBEF increased progressively over time, with values of 36% \u00b1 20% at 30 min, 50% \u00b1 23% at 45 min, and 55% \u00b1 23% at 60 min, demonstrating statistically significant differences across time points (\n P<\/jats:italic>\n < 0.0001). No significant differences in GBEF were observed between males and females at any time point (\n P<\/jats:italic>\n \u2265 0.770). In addition, age was not significantly correlated with GBEF at any measured time point (\n P<\/jats:italic>\n \u2265 0.820). The reference value of GBEF, determined based on the 5\n th<\/jats:sup>\n percentile at 60 min postmeal ingestion, was established as \u226520%, providing a clinically relevant threshold for assessing gallbladder function.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The study established the reference value of GBEF using a standard fatty meal protocol. In addition, using a culturally appropriate, low-cost fatty meal offers a practical alternative to sincalide-based cholescintigraphy, especially where sincalide is scarce or quality control is challenging. This patient-friendly method also shortens imaging sessions, reducing discomfort. These values support diagnostic thresholds in clinical practice.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijnm.ijnm_24_25","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T14:00:31Z","timestamp":1758290431000},"page":"204-210","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Reference Values for Gallbladder Ejection Fraction in a Healthy Indian Cohort Using Fatty Meal Hepatobiliary Scintigraphy"],"prefix":"10.25259","volume":"40","author":[{"given":"Ashutosh","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asem Rangita","family":"Chanu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dikhra","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangkim Chandra","family":"Khangembam","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"R1-20250922","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cgh.2011.02.013","article-title":"Cholecystokinin-cholescintigraphy in adults: Consensus recommendations of an interdisciplinary panel","volume":"9","author":"DiBaise","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R2-20250922","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/RLU.0b013e31823e26bb","article-title":"Cholecystokinin-cholescintigraphy in adults: Consensus recommendations of an interdisciplinary panel","volume":"37","author":"DiBaise","year":"2012","journal-title":"Clin Nucl Med"},{"key":"R3-20250922","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2967\/jnumed.113.131490","article-title":"Hepatobiliary scintigraphy in 2014","volume":"55","author":"Ziessman","year":"2014","journal-title":"J Nucl Med"},{"key":"R4-20250922","first-page":"93","article-title":"The physiology of the biliary tree. 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