{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:05:57Z","timestamp":1779696357612,"version":"3.53.1"},"reference-count":16,"publisher":"Scientific Scholar","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    A 69-year-old gentleman presented with complains of giddiness, gait ataxia, vomiting, and slurring of speech with clinical signs pointing to cerebellar etiology. The magnetic resonance imaging brain revealed no significant abnormality.\n                    <jats:sup>18<\/jats:sup>\n                    F-fluorodeoxyglucose (\n                    <jats:sup>18<\/jats:sup>\n                    F FDG) positron emission tomography (PET)\/computed tomography showed hyper-metabolism in bilateral cerebellar hemispheres, pons, mid-brain and bilateral medial temporal cortices. Further quantitative NeuroQ analysis of\n                    <jats:sup>18<\/jats:sup>\n                    F FDG-PET showed similar findings. Paraneoplastic antibody panel (anti-Hu, anti-Yo, anti-Ri, NMDA, CASPR-2 etc.) was negative. Clinical suspicion and PET imaging correlation led the neurologist to suspicion of inflammatory\/autoimmune etiology, and the patient was empirically started on four cycles of plasma exchange therapy and course of steroids, however, no significant clinical response was noted. At post-6 months of\n                    <jats:sup>18<\/jats:sup>\n                    F FDG-PET, he expired out of respiratory illness (pneumonia).\n                  <\/jats:p>","DOI":"10.4103\/ijnm.ijnm_26_25","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T14:00:14Z","timestamp":1758290414000},"page":"240-243","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Striking Bilateral Cerebellar Hypermetabolism on 18F FDG-PET in a Patient of Sudden Onset Gait Ataxia with Absence of Paraneoplastic Antibody and Other Localizing Imaging Indicator"],"prefix":"10.25259","volume":"40","author":[{"given":"Parth","family":"Baberwal","sequence":"first","affiliation":[{"name":"Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Mumbai, Maharashtra, India"},{"name":"Homi Bhabha National Institute, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita Nitin","family":"Sonavane","sequence":"additional","affiliation":[{"name":"Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Mumbai, Maharashtra, India"},{"name":"Homi Bhabha National Institute, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Basu","sequence":"additional","affiliation":[{"name":"Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Mumbai, Maharashtra, India"},{"name":"Homi Bhabha National Institute, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"R1-20250922","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1053\/j.semnuclmed.2021.01.002","article-title":"Brain [F-18] FDG PET for clinical dementia workup: Differential diagnosis of Alzheimer\u2019s disease and other types of dementing disorders","volume":"51","author":"Minoshima","year":"2021","journal-title":"Semin Nucl Med"},{"key":"R2-20250922","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1053\/j.semnuclmed.2020.12.002","article-title":"Molecular and anatomical imaging of dementia with lewy bodies and frontotemporal lobar degeneration","volume":"51","author":"Duignan","year":"2021","journal-title":"Semin Nucl Med"},{"key":"R3-20250922","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.nrl.2022.08.001","article-title":"Cerebellar hypermetabolism: An alternative marker for diagnosis of paraneoplastic cerebellar degeneration","volume":"38","author":"Arslan","year":"2023","journal-title":"Neurologia (Engl Ed)"},{"key":"R4-20250922","doi-asserted-by":"crossref","first-page":"e10717","DOI":"10.1097\/MD.0000000000010717","article-title":"Paraneoplastic cerebellar degeneration associated with cerebellar hypermetabolism: Case report","volume":"97","author":"Abdulaziz","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"R5-20250922","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1136\/jnnp.2005.075325","article-title":"Cerebellar hypermetabolism in paraneoplastic cerebellar degeneration","volume":"77","author":"Choi","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R6-20250922","first-page":"79","article-title":"Cerebellar hypermetabolism on \u00b9\u2078F-FDG PET\/CT with normal MRI in a case of paraneoplastic cerebellar degeneration with negative antibodies","volume":"34","author":"Sharma","year":"2015","journal-title":"Rev Esp Med Nucl Imagen Mol"},{"key":"R7-20250922","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1097\/MNM.0000000000000163","article-title":"Brain 18F-FDG-PET characteristics in patients with paraneoplastic neurological syndrome and its correlation with clinical and MRI findings","volume":"35","author":"Masangkay","year":"2014","journal-title":"Nucl Med Commun"},{"key":"R8-20250922","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neurol.2021.07.018","article-title":"Autoimmune cerebellar hypermetabolism: Report of three cases and literature overview","volume":"178","author":"Brunet","year":"2022","journal-title":"Rev Neurol (Paris)"},{"key":"R9-20250922","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3390\/diagnostics10060356","article-title":"(18)F-FDG-PET imaging patterns in autoimmune encephalitis: Impact of image analysis on the results","volume":"10","author":"Moreno-Ajona","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"R10-20250922","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1212\/WNL.42.10.1931","article-title":"Paraneoplastic cerebellar degeneration. I. A clinical analysis of 55 anti-Yo antibody-positive patients","volume":"42","author":"Peterson","year":"1992","journal-title":"Neurology"},{"key":"R11-20250922","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/RLU.0b013e31821a2604","article-title":"Cerebral hypermetabolism demonstrated by FDG PET in familial Creutzfeldt-Jakob disease","volume":"36","author":"Nagasaka","year":"2011","journal-title":"Clin Nucl Med"},{"key":"R12-20250922","article-title":"Alzheimer's Disease Neuroimaging Initiative","author":"Meadowcroft","year":"2020","journal-title":"bioRxiv"},{"key":"R13-20250922","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1007\/s00259-021-05358-4","article-title":"Diffuse cerebellar hypermetabolism: An early sign of leptomeningeal metastases","volume":"48","author":"Broen","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"R14-20250922","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11307-008-0134-7","article-title":"Role of FDG-PET in the clinical management of paraneoplastic neurological syndrome: Detection of the underlying malignancy and the brain PET-MRI correlates","volume":"10","author":"Basu","year":"2008","journal-title":"Mol Imaging Biol"},{"key":"R15-20250922","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4103\/0972-3919.125781","article-title":"Isolated cerebellar hypermetabolism on FDG PET in a case of remitted primary breast lymphoma","volume":"29","author":"Reddy","year":"2014","journal-title":"Indian J Nucl Med"},{"key":"R16-20250922","doi-asserted-by":"crossref","first-page":"e506","DOI":"10.1212\/NXI.0000000000000506","article-title":"FDG-PET abnormalities leading to the diagnosis of an unusual case of probable neurosarcoidosis","volume":"5","author":"Wang","year":"2018","journal-title":"Neurol Neuroimmunol Neuroinflamm"}],"container-title":["Indian Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/ijnm.ijnm_26_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:38:31Z","timestamp":1779694711000},"score":1,"resource":{"primary":{"URL":"https:\/\/ijnm.co.in\/striking-bilateral-cerebellar-hypermetabolism-on-18f-fdg-pet-in-a-patient-of-sudden-onset-gait-ataxia-with-absence-of-paraneoplastic-antibody-and-other-localizing-imaging-indicator\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijnm.ijnm_26_25","relation":{},"ISSN":["0972-3919","0974-0244"],"issn-type":[{"value":"0972-3919","type":"print"},{"value":"0974-0244","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-02-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}