{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:05:42Z","timestamp":1779696342254,"version":"3.53.1"},"reference-count":12,"publisher":"Scientific Scholar","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"\n Introduction:<\/jats:title>\n \n Recurrent\/persistent primary hyperparathyroidism in patients who have undergone previous parathyroidectomy is a challenging condition. Imaging is important for localizing the parathyroid adenoma for re-exploration and\n 18<\/jats:sup>\n F-Fluorocholine (\n 18<\/jats:sup>\n F-FCH) positron emission tomography\/computed tomography (PET\/CT) seems ideal for this purpose.\n <\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n \n This prospective study attempted to ascertain the utility of\n 18<\/jats:sup>\n F-FCH PET\/CT as an investigation in preoperative localization of abnormal parathyroid tissue in recurrent\/persistent primary hyperparathyroidism while comparing it with\n 99m<\/jats:sup>\n Tc-Sestamibi dual-phase scintigraphy with early single-photon emission CT (SPECT)\/CT and neck ultrasonography (USG).\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Twenty patients with biochemical features of recurrent\/persistent primary hyperparathyroidism were enrolled into this study. They underwent neck USG,\n 99m<\/jats:sup>\n Tc-Sestamibi dual-phase scintigraphy with early SPECT\/CT and\n 18<\/jats:sup>\n F-FCH PET\/CT for localization of parathyroid lesions. Six patients underwent surgical resection of the detected lesions, 3 were awaiting surgery, and 11 were managed conservatively. One patient died due to COVID.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The calculated positive predictive values on a per-lesion basis of neck USG,\n 99m<\/jats:sup>\n Tc-sestamibi scintigraphy and early SPECT\/CT and\n 18<\/jats:sup>\n F-FCH PET\/CT in the cohort of the 5 operated patients were 75% (3\/4), 71.4% (5\/7), and 71.4% (5\/7), respectively. On a per-patient basis, the lesion detection rate was 100% for\n 99m<\/jats:sup>\n Tc-sestamibi scan and FCH PET (5\/5) and 80% on neck USG (4\/5).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n 18<\/jats:sup>\n F-FCH PET\/CT is a highly accurate imaging modality for the detection of parathyroid lesions in patients with recurrent\/persistent primary hyperparathyroidism.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijnm.ijnm_31_22","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T03:00:19Z","timestamp":1697166019000},"page":"218-223","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Role of 18Fluorocholine Positron Emission Tomography\/Computed Tomography in the Localization of Culprit Lesions in Patients of Persistent\/Recurrent Primary Hyperparathyroidism: A Prospective Study in COVID Times"],"prefix":"10.25259","volume":"38","author":[{"given":"Ritwik","family":"Wakankar","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamini","family":"Dharmashaktu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Nishikant","family":"Damle","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrasekhar","family":"Bal","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavi","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipra","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Khadgawat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Chumber","sequence":"additional","affiliation":[{"name":"Department of Surgery, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitresh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"R1-20240902","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13550-019-0544-3","article-title":"Parathyroid imaging with 18F-fluorocholine PET\/CT as a first-line imaging modality in primary hyperparathyroidism: A retrospective cohort study","volume":"9","author":"Broos","year":"2019","journal-title":"EJNMMI Res"},{"key":"R2-20240902","article-title":"Re-do Parathyroid Surgery"},{"key":"R3-20240902","doi-asserted-by":"crossref","first-page":"e1701","DOI":"10.1097\/MD.0000000000001701","article-title":"A pilot comparison of 18F-fluorocholine PET\/CT, ultrasonography and 123I\/99mTc-sestaMIBI dual-phase dual-isotope scintigraphy in the preoperative localization of hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism: Influence of thyroid anomalies","volume":"94","author":"Michaud","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"R4-20240902","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1007\/s00259-017-3911-1","article-title":"F18-choline PET\/CT guided surgery in primary hyperparathyroidism when ultrasound and MIBI SPECT\/CT are negative or inconclusive: The apach1 study","volume":"45","author":"Quak","year":"2018","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"R5-20240902","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1007\/s00259-018-4147-4","article-title":"Additional value of integrated 18F-choline PET\/4D contrast-enhanced CT in the localization of hyperfunctioning parathyroid glands and correlation with molecular profile","volume":"46","author":"Piccardo","year":"2019","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"R6-20240902","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1007\/s00268-019-04910-6","article-title":"18F-fluorocholine PET\/CT and parathyroid 4D computed tomography for primary hyperparathyroidism: The challenge of reoperative patients","volume":"43","author":"Amadou","year":"2019","journal-title":"World J Surg"},{"key":"R7-20240902","doi-asserted-by":"crossref","first-page":"399","DOI":"10.4103\/ijem.IJEM_536_16","article-title":"Comparison of 18F-fluorocholine positron emission tomography\/computed tomography and four-dimensional computed tomography in the preoperative localization of parathyroid adenomas-initial results","volume":"21","author":"Taywade","year":"2017","journal-title":"Indian J Endocrinol Metab"},{"key":"R8-20240902","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s00405-019-05301-2","article-title":"The role of F18-fluorocholine positron emission tomography\/magnetic resonance imaging in localizing parathyroid adenomas","volume":"276","author":"Khafif","year":"2019","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"R9-20240902","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/9649564","article-title":"Localization of parathyroid disease in reoperative patients with primary hyperparathyroidism","volume":"2020","author":"Parikh","year":"2020","journal-title":"Int J Endocrinol"},{"key":"R10-20240902","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00268-011-1365-3","article-title":"Parathyroid four-dimensional computed tomography: Evaluation of radiation dose exposure during preoperative localization of parathyroid tumors in primary hyperparathyroidism","volume":"36","author":"Mahajan","year":"2012","journal-title":"World J Surg"},{"key":"R11-20240902","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1088\/1361-6498\/aaa86f","article-title":"18F-choline PET\/CT for parathyroid scintigraphy: Significantly lower radiation exposure of patients in comparison to conventional nuclear medicine imaging approaches","volume":"38","author":"Rep","year":"2018","journal-title":"J Radiol Prot"},{"key":"R12-20240902","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1097\/MNM.0000000000000924","article-title":"Assessment of the role of early dynamic PET\/CT with 18F-fluorocholine in detection of parathyroid lesions in patients with primary hyperparathyroidism","volume":"39","author":"Prabhu","year":"2018","journal-title":"Nucl Med Commun"}],"container-title":["Indian Journal of Nuclear 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History"}},{"value":"2023-01-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}