{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:24:13Z","timestamp":1787765053527,"version":"build-2784847793"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study aims to report the outcomes of Bowman\u2013Stromal Inlay (BSI) versus corneal collagen crosslinking (CXL) in patients with progressive keratoconus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective, nonrandomized, interventional, comparative study included 16 patients (n = 32 eyes) with bilateral keratoconus. We analyzed the medical records of patients who had undergone CXL in one eye and BSI in the other, with a minimum follow-up period of 12 months. The medical records were reviewed for outcomes in the form of refractive and tomographic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 16 patients (32 eyes; 16 CXL, 16 BSI) were included in the study. The mean follow-up period was 30.64 \u00b1 6.14 months in the CXL group and 29.5 \u00b1 5.9 months in the BSI group (range: 6 \u2013 61 months). The visual improvement after surgery was better in the BSI group compared to the CXL group, although the changes were not statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      (UCVA) = 0.25,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      (BCVA) = 0.56). No change was observed in the post-operative Kmax and Kmean values throughout the follow-up period in both groups. The postoperative corneal thickness increased significantly in the BSI group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), while it remained unchanged in the CXL group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.14). After these initial postoperative changes, the pachymetry remained stable throughout the follow-up period. The BSI group showed a significant improvement in asphericity (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02) postoperatively, whereas asphericity remained unchanged after CXL (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.89). Topographic astigmatism did not show significant changes in either group after surgery compared to the preoperative values. Neither group had any eyes showing the progression of tomographic parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Both CXL and BSI demonstrated efficacy in preventing the progression of ectasia in keratoconus. BSI showed additional benefits of improved asphericity and increased pachymetry compared to CXL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1013_24","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T07:00:13Z","timestamp":1751266813000},"page":"966-973","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Clinical outcomes of Bowman-Stromal inlay and corneal collagen crosslinking in contralateral eyes in patients with progressive keratoconus"],"prefix":"10.4103","volume":"73","author":[{"given":"Neha","family":"Jain","sequence":"first","affiliation":[{"name":"Cornea and Anterior Segment Services, L J Eye Institute, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Mittal","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment Services, L J Eye Institute, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yatri","family":"Pandya","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment Services, L J Eye Institute, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibha","family":"Yadav","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment Services, L J Eye Institute, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwa","family":"Shah","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment Services, L J Eye Institute, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debapriya","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment Services, L J Eye Institute, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"R1-20260421","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jmbbm.2010.09.014","article-title":"The effect of keratoconus on the structural, mechanical, and optical properties of the cornea","volume":"4","author":"Ambekar","year":"2011","journal-title":"J Mech Behav Biomed Mater"},{"key":"R2-20260421","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/ijo.IJO_1403_18","article-title":"Current concepts in crosslinking thin corneas","volume":"67","author":"Deshmukh","year":"2019","journal-title":"Indian J Ophthalmol"},{"key":"R3-20260421","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"Wollensak","year":"2003","journal-title":"Am J 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