{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:49:26Z","timestamp":1792154966760,"version":"4.4.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the epidemiological characteristics, clinical features, and treatment outcomes of microsporidial keratoconjunctivitis (MKC) over a 10-year period at a tertiary eye care center in central India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study analyzed patients diagnosed with MKC between 2015 and 2024. Data from 2005 to 2014 were additionally used to determine hospital-based incidence and prevalence trends. Diagnosis was based on the detection of microsporidial spores in corneal scrapings or characteristic slit-lamp findings. Trends were compared between the two periods (2015\u20132019 and 2020\u20132024).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 284,211 outpatients seen between 2005 and 2024, 520 (0.2%) were diagnosed with MKC; 393 patients (402 eyes) from 2015 to 2024 were included in the study. The median age was 33 years, with male predominance (64.4%). Most patients were from urban areas (67.9%) and engaged in indoor or sedentary work (81.7%). A significant increase in rural representation and outdoor\/manual occupations was observed from 2020 to 2024 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.019 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.018, respectively). Seasonal clustering persisted throughout the rainy season. Minor ocular trauma was reported in 40.7% of cases. The incidence of concurrent diabetes mellitus increased over time. Primary epithelial debridement was performed in 88.1% of patients and was associated with faster epithelial resolution (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). No treatment failures were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>MKC is a seasonally patterned infection with evolving epidemiological characteristics. Increased awareness has led to more diagnoses. Increasing rural representation and associated diabetes require further studies. Although typically self-limiting, epithelial debridement may shorten the resolution time and needs to be explored further as a treatment option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1033_26","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:01:19Z","timestamp":1792152079000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Microsporidial keratoconjunctivitis in Central India: Epidemiological trends and outcomes over 10 years"],"prefix":"10.4103","author":[{"given":"Samrat","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Department of Cornea and Anterior Segment, MGM Eye Institute, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepshikha","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Cornea and Anterior Segment, MGM Eye Institute, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha","family":"Goklani","sequence":"additional","affiliation":[{"name":"Department of Cornea and Anterior Segment, MGM Eye Institute, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,16]]},"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_1033_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:01:19Z","timestamp":1792152079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_1033_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,16]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_1033_26","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,16]]},"assertion":[{"value":"2026-04-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}