{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T22:47:56Z","timestamp":1794091676057,"version":"4.8.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare the diagnostic ability of the ganglion cell analysis (GCA) and retinal nerve fiber layer (RNFL) protocol on optical coherence tomography (OCT), to diagnose preperimetric glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective, cross-sectional study of 275 adult patients including 47 early glaucoma (mean deviation better than -6.0 D), 150 glaucoma suspects (106 with suspicious discs and 44 ocular hypertensive (OHT), and 78 normal controls was done. Eligible participants were scanned with the spectral domain Cirrus\u2122 OCT (Carl Zeiss Meditec, Dublin, CA). Average peripapillary RNFL thickness and GCA measurements were obtained. Area under receiver operating characteristic (AROC) curves were used to evaluate discriminant value of both protocols to diagnose likely preperimetric glaucoma among glaucoma suspects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Average RNFL and GCA were significantly thinner in glaucoma patients compared to glaucoma suspects and normal controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The RNFL was 92.26 \u00b1 8.8 \u03bc in normal controls, 87.9 \u00b1 12.12 \u03bc in glaucoma suspects and significantly thinner in POAG (70.29 \u00b1 10.18 \u03bc;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The GCA was 81.94 \u00b1 6.17 \u03bc in normal controls, 77.69 \u00b1 9.03 \u03bc in glaucoma suspects, and significantly thinner in POAG (69.36 \u00b1 11.06 \u03bc;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). AROCs for discriminating glaucoma suspects from normal were modest, with no difference in AROC of average RNFL or GCA measurements (DeLong;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.93). Average RNFL thickness had significantly greater AROC values than average GCA for discriminating glaucoma suspects (both suspicious discs and OHT) from glaucoma (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03 and 0.05, respectively. AROC for diagnosing glaucoma was significantly better (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02) for RNFL (0.88 \u00b1 0.03) than GCA (0.77 \u00b1 0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In the present time, GCA measurements, as provided by the SD-OCT, do not appear to outperform RNFL measurements in the diagnosis of preperimetric glaucoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1039_17","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T01:46:39Z","timestamp":1522028799000},"page":"511-516","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Evaluation of macular ganglion cell analysis compared to retinal nerve fiber layer thickness for preperimetric glaucoma diagnosis"],"prefix":"10.4103","volume":"66","author":[{"given":"Sushmita","family":"Kaushik","sequence":"first","affiliation":[{"name":"Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Kataria","sequence":"additional","affiliation":[{"name":"Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav","family":"Jain","sequence":"additional","affiliation":[{"name":"Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunjan","family":"Joshi","sequence":"additional","affiliation":[{"name":"Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 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