{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:49:14Z","timestamp":1788587354047,"version":"build-2803163510"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Dry eye syndrome (DES) is a familiar sequelae of radiation therapy (RT) for head and neck cancers (HNC). Ocular surface changes such as DES occur due to injury to the conjunctival epithelium, goblet cells, corneal surface, lacrimal glands, and meibomian glands. This study aimed at the evaluation and early detection of changes in ocular surface parameters in patients receiving RT for extraocular HNC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty-two eyes of 21 patients undergoing HNC RT were evaluated. Radiation technique and dose of radiation to the lens and eye were recorded. Subjects were evaluated for meibomian gland changes by meiboscore grading, ocular surface disease index (OSDI) questionnaire, Schirmer\u2019s test, tear film break-up time (TBUT), and slit-lamp examination before RT, immediately post RT, and 6 weeks post RT. A comparison of the ipsilateral eye on the irradiated side to the contralateral eye was done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A significant reduction in TBUT was seen immediately post RT and 6 weeks post RT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 and 0.008, respectively), with an increase in meiboscore at both visits (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). An OSDI score of &gt;13 was seen in 23.80% of patients post RT, with a significant difference from baseline (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). On comparing ipsilateral and contralateral eye groups, a significant difference from baseline was seen in TBUT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 and 0.033, respectively) and meiboscore (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 for both eyes). A significant change of &gt;1 second in TBUT and &gt;1.7 in meiboscore was seen with a mean dose of around 8 Gy to the lens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>All patients undergoing HNC RT should be followed up for ocular surface and meibomian gland changes. The contralateral eye should also be evaluated. Patients receiving lower doses to the ocular structures should also be kept under follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1080_23","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T02:00:21Z","timestamp":1708653621000},"page":"S669-S675","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Ocular surface changes in patients who have undergone head and neck radiation therapy"],"prefix":"10.4103","volume":"72","author":[{"given":"H","family":"Sujithra","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Amrita Institute of Medical Sciences Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannisha N","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Amrita Institute of Medical Sciences Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Anoop","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Amrita Institute of Medical Sciences Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpaja K","family":"Ullattil","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Amrita Institute of Medical Sciences Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal S","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Amrita Institute of Medical Sciences Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greeshma C","family":"Ravindran","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Amrita Institute of Medical Sciences Kochi, Kerala, 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