{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:20:52Z","timestamp":1787761252530,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>We present a case of large peripapillary polypoidal choroidal vasculopathy treated with standard-fluence photodynamic therapy (PDT) as other treatment options were unsuccessful or not justified. Due to large lesion size, treatment spot included part of optic disc also. PDT resulted in regression of polyp and visual improvement (from 20\/300 to 20\/20) without any collateral damage to optic nerve as evidenced by visual-field test and visual-evoked potential with a follow-up till 2 years. This case highlights the role of PDT as a safe alternative for treatment of large peripapillary lesion, even though the treatment spot encompasses part of the optic nerve head.<\/jats:p>","DOI":"10.4103\/ijo.ijo_1081_19","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:59:49Z","timestamp":1582160389000},"page":"530-533","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Safety of photodynamic therapy involving optic nerve head"],"prefix":"10.4103","volume":"68","author":[{"given":"George Joseph","family":"Manayath","sequence":"first","affiliation":[{"name":"Aravind Eye Hospital, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishir","family":"Verghese","sequence":"additional","affiliation":[{"name":"Aravind Eye Hospital, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhee","family":"Jain","sequence":"additional","affiliation":[{"name":"Aravind Eye Hospital, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratnesh","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Aravind Eye Hospital, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatapathy","family":"Narendran","sequence":"additional","affiliation":[{"name":"Aravind Eye Hospital, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,2,14]]},"reference":[{"key":"R1-20251013","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ophtha.2017.11.019","article-title":"Polypoidal choroidal vasculopathy: Definition, pathogenesis, diagnosis, and management","volume":"125","author":"Cheung","year":"2018","journal-title":"Ophthalmology"},{"key":"R2-20251013","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1097\/IAE.0b013e31824f91e8","article-title":"EVEREST study: Efficacy and safety of verteporfin photodynamic therapy in combination with ranibizumab or alone versus ranibizumab monotherapy in patients with symptomatic macular polypoidal choroidal vasculopathy","volume":"32","author":"Koh","year":"2012","journal-title":"Retina"},{"key":"R3-20251013","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s12886-018-0937-5","article-title":"A rodent model of anterior ischemic optic neuropathy (AION) based on laser photoactivation of verteporfin","volume":"18","author":"Min","year":"2018","journal-title":"BMC Ophthalmol"},{"key":"R4-20251013","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/IAE.0b013e31815e9351","article-title":"Verteporfin photodynamic therapy involving the optic nerve for peripapillary choroidal neovascularization","volume":"28","author":"Bernstein","year":"2008","journal-title":"Retina"},{"key":"R5-20251013","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0161-6420(99)90401-3","article-title":"Verteporfin photodynamic therapy retreatment of normal retina and choroid in the cynomolgus monkey","volume":"106","author":"Reinke","year":"1999","journal-title":"Ophthalmology"},{"key":"R6-20251013","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s00417-002-0517-4","article-title":"Dose-related structural effects of photodynamic therapy on choroidal and retinal structures of human eyes","volume":"240","author":"Schl\u00f6tzer-Schrehardt","year":"2002","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R7-20251013","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/ICB.0b013e31813c677a","article-title":"Idiopathic juxtapapillary polypoidal choroidal vasculopathy in the papillomacular bundle: Treatment with photodynamic therapy: Two years' follow-up","volume":"2","author":"Vilaplana","year":"2008","journal-title":"Retin Cases Brief Rep"},{"key":"R8-20251013","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/ICB.0b013e31814c3ee8","article-title":"Photodynamic therapy directly over the optic nerve head to treat peripapillary hemangioma","volume":"2","author":"Navea-Tejerina","year":"2008","journal-title":"Retin Cases Brief Rep"},{"key":"R9-20251013","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/ICB.0b013e31828ef04c","article-title":"Successful resolution of endophytic optic disc hemangioma by photodynamic therapy","volume":"7","author":"Fukumoto","year":"2013","journal-title":"Retin Cases Brief Rep"},{"key":"R10-20251013","doi-asserted-by":"crossref","first-page":"754","DOI":"10.4103\/ijo.IJO_41_16","article-title":"Therapeutic surprise! Photodynamic therapy for cavernous haemangioma of the disc","volume":"65","author":"Shanmugam","year":"2017","journal-title":"Indian J Ophthalmol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_1081_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:29:13Z","timestamp":1787758153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_1081_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,14]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_1081_19","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,14]]},"assertion":[{"value":"2019-06-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}