{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:41:28Z","timestamp":1786718488615,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Ophthalmol"],"published-print":{"date-parts":[[2018]]},"DOI":"10.4103\/ijo.ijo_108_18","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T02:56:32Z","timestamp":1532314592000},"page":"1104","source":"Crossref","is-referenced-by-count":23,"title":["Therapeutic potential of valproic acid in advanced glaucoma: A pilot study"],"prefix":"10.4103","volume":"66","author":[{"given":"Viney","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthikeyan","family":"Mahalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AbadhKumar","family":"Chaurasia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshminarayanan","family":"Gowtham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BinduI","family":"Somarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thirumurthy","family":"Velpandian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanjit","family":"Sihota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0301-4738.237303-1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0161-6420(82)34675-8","article-title":"Why do some people go blind from glaucoma?","author":"Grant","year":"1982","journal-title":"Ophthalmology"},{"key":"key-10.4103\/0301-4738.237303-2","first-page":"539","article-title":"Visual prognosis in advanced glaucoma: A comparison of medical and surgical therapy for retention of vision in 101 eyes with advanced glaucoma","author":"Kolker","year":"1977","journal-title":"Trans Am Ophthalmol Soc"},{"key":"key-10.4103\/0301-4738.237303-3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1755-3768.1987.tb02583.x","article-title":"Visual field prognosis in advanced glaucoma","author":"Odberg","year":"1987","journal-title":"Acta Ophthalmol"},{"key":"key-10.4103\/0301-4738.237303-4","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1167\/iovs.03-0566","article-title":"Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, I: Functional measures","author":"Hare","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key-10.4103\/0301-4738.237303-5","first-page":"1","article-title":"Use of animal models and techniques in glaucoma research: Introduction","author":"Quigley","year":"2018","journal-title":"Methods Mol Biol"},{"key":"key-10.4103\/0301-4738.237303-6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1054\/mehy.1999.0025","article-title":"Potential role for ginkgo biloba extract in the treatment of glaucoma","author":"Ritch","year":"2000","journal-title":"Med Hypotheses"},{"key":"key-10.4103\/0301-4738.237303-7","first-page":"CD006539","article-title":"Neuroprotection for treatment of glaucoma in adults","author":"Sena","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"key-10.4103\/0301-4738.237303-8","doi-asserted-by":"crossref","unstructured":"Zhong Y, Xiang M, Ye W, Cheng Y, Jiang Y. Visual field protective effect of erigeron breviscapus (vant.) hand. mazz. extract on glaucoma with controlled intraocular pressure: A randomized, double-blind, clinical trial. Drugs R D 2010;10:75-82.","DOI":"10.2165\/11539090-000000000-00000"},{"key":"key-10.4103\/0301-4738.237303-9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/bjo.2009.175356","article-title":"Therapeutic potential of valproic acid for retinitis pigmentosa","author":"Clemson","year":"2011","journal-title":"Br J Ophthalmol"},{"key":"key-10.4103\/0301-4738.237303-10","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.2147\/OPTH.S109995","article-title":"Efficacy of valproic acid for retinitis pigmentosa patients: A pilot study","author":"Iraha","year":"2016","journal-title":"Clin Ophthalmol"},{"key":"key-10.4103\/0301-4738.237303-11","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1089\/jop.2013.0166","article-title":"Efficacy of oral valproic acid in patients with retinitis pigmentosa","author":"Kumar","year":"2014","journal-title":"J Ocul Pharmacol Ther"},{"key":"key-10.4103\/0301-4738.237303-12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s40123-012-0006-8","article-title":"Effect of short-term oral valproic acid on vision and visual field in retinitis pigmentosa","author":"Shanmugam","year":"2012","journal-title":"Ophthalmol Ther"},{"key":"key-10.4103\/0301-4738.237303-13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neulet.2014.12.054","article-title":"Valproic acid prevents retinal degeneration in a murine model of normal tension glaucoma","author":"Kimura","year":"2015","journal-title":"Neurosci Lett"},{"key":"key-10.4103\/0301-4738.237303-14","first-page":"124","article-title":"Valproic acid-mediated neuroprotection and neuroregeneration in optic nerve injury is associated with CREB-induction and activation of pERK1\/2","author":"Lasseck","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key-10.4103\/0301-4738.237303-15","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.nbd.2007.02.006","article-title":"Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation","author":"Sinn","year":"2007","journal-title":"Neurobiol Dis"},{"key":"key-10.4103\/0301-4738.237303-16","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1523\/JNEUROSCI.1139-07.2007","article-title":"Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model","author":"Rouaux","year":"2007","journal-title":"J Neurosci"},{"key":"key-10.4103\/0301-4738.237303-17","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1523\/JNEUROSCI.5747-03.2004","article-title":"Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis","author":"Hao","year":"2004","journal-title":"J Neurosci"},{"key":"key-10.4103\/0301-4738.237303-18","doi-asserted-by":"crossref","first-page":"31674","DOI":"10.1074\/jbc.M104309200","article-title":"The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth","author":"Yuan","year":"2001","journal-title":"J Biol Chem"},{"key":"key-10.4103\/0301-4738.237303-19","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1136\/bjo.84.10.1147","article-title":"Pilot study of the multifocal electroretinogram in ocular hypertension","author":"Chan","year":"2000","journal-title":"Br J Ophthalmol"},{"key":"key-10.4103\/0301-4738.237303-20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1444-0938.2010.00571.x","article-title":"Applications of the multifocal electroretinogram in the detection of glaucoma","author":"Chan","year":"2011","journal-title":"Clin Exp Optom"},{"key":"key-10.4103\/0301-4738.237303-21","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1136\/bjophthalmol-2014-305323","article-title":"Comparing focal and global responses on multifocal electroretinogram with retinal nerve fibre layer thickness by spectral domain optical coherence tomography in glaucoma","author":"Rao","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"key-10.4103\/0301-4738.237303-22","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1136\/bjophthalmol-2013-303084","article-title":"Long-term follow-up for efficacy and safety of treatment of retinitis pigmentosa with valproic acid","author":"Bhalla","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"key-10.4103\/0301-4738.237303-23","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1136\/bjophthalmol-2012-301950","article-title":"Valproic acid treatment may be harmful in non-dominant forms of retinitis pigmentosa","author":"Sisk","year":"2012","journal-title":"Br J Ophthalmol"},{"key":"key-10.4103\/0301-4738.237303-24","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1152\/jn.00144.2007","article-title":"Emergence of sustained spontaneous hyperactivity and temporary preservation of OFF responses in ganglion cells of the retinal degeneration (rd1) mouse","author":"Stasheff","year":"2008","journal-title":"J Neurophysiol"},{"key":"key-10.4103\/0301-4738.237303-25","first-page":"395","article-title":"Histone deacetylase inhibitors sodium butyrate and valproic acid delay spontaneous cell death in purified rat retinal ganglion cells","author":"Biermann","year":"2011","journal-title":"Mol Vis"},{"key":"key-10.4103\/0301-4738.237303-26","doi-asserted-by":"crossref","first-page":"7486","DOI":"10.1167\/iovs.14-14792","article-title":"Acetylation preserves retinal ganglion cell structure and function in a chronic model of ocular hypertension","author":"Alsarraf","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key-10.4103\/0301-4738.237303-27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ajo.2005.07.044","article-title":"Categorizing the stage of glaucoma from pre-diagnosis to end-stage disease","author":"Mills","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"key-10.4103\/0301-4738.237303-28","first-page":"125","article-title":"Side effects of sodium valproate during long-term treatment in epilepsy","author":"Ruuskanen","year":"1979","journal-title":"Acta Neurol Scand"},{"key":"key-10.4103\/0301-4738.237303-29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1054\/jocn.2001.1015","article-title":"Visual functions in epilepsy patients on valproate monotherapy","author":"Ozkul","year":"2002","journal-title":"J Clin Neurosci"},{"key":"key-10.4103\/0301-4738.237303-30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.seizure.2005.04.010","article-title":"Visual function in epilepsy patients treated with initial valproate monotherapy","author":"Sorri","year":"2005","journal-title":"Seizure"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:35:40Z","timestamp":1786714540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_108_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018]]}},"alternative-id":["237303"],"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_108_18","relation":{},"ISSN":["0301-4738"],"issn-type":[{"value":"0301-4738","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]}}}