{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:21:05Z","timestamp":1787761265995,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Optic nerve aplasia (ONA) is a congenital optic nerve anomaly characterized by the absence of optic nerve head, retinal blood vessels, retinal ganglion cells, and optic nerve fibers in a malformed eye. Clinically, the condition presents with the absence of perception of light, afferent pupillary defect and a fundus appearance of absent optic nerve head, and retinal vessels with associated ocular and nonocular abnormalities. Systemic anomalies have been reported with bilateral ONA, whereas unilateral ONA is seen in otherwise healthy individuals. We report three cases of ONA with varied clinical presentations.<\/jats:p>","DOI":"10.4103\/ijo.ijo_1108_17","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T08:09:28Z","timestamp":1524211768000},"page":"717-719","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Optic nerve aplasia: A case series"],"prefix":"10.4103","volume":"66","author":[{"given":"K Samyukta","family":"Sadasivan","sequence":"first","affiliation":[{"name":"Department of Paediatric Ophthalmology and Squint, Aravind Eye Hospital, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Pawar","sequence":"additional","affiliation":[{"name":"Department of Paediatric Ophthalmology and Squint, Aravind Eye Hospital, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Ravindran","sequence":"additional","affiliation":[{"name":"Department of Paediatric Ophthalmology and Squint, Aravind Eye Hospital, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramakrishnan","family":"Rengappa","sequence":"additional","affiliation":[{"name":"Chief Medical Officer, Aravind Eye Hospital, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251013","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1001\/archopht.122.1.125","article-title":"Optic Nerve Aplasia in an Infant with Congenital Hypopituitarism and Posterior Pituitary Ectopia","volume":"122","author":"Brodsky","year":"2004","journal-title":"Archives of ophthalmology"},{"key":"R3-20251013","first-page":"61","article-title":"Aplasia of the optic nerve","volume":"26","author":"Scheie","year":"1941","journal-title":"J Pediatr Ophthalmol"},{"key":"R5-20251013","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/archopht.1978.03910050053013","article-title":"Bilateral optic system aplasia with relatively normal eyes","volume":"96","author":"Yanoff","year":"1978","journal-title":"Arch Ophthalmol"},{"key":"R6-20251013","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3928\/0191-3913-19790701-06","article-title":"Optic nerve aplasia and hypoplasia","volume":"16","author":"Hotchkiss","year":"1979","journal-title":"J Pediatr ophthalmol Strabismus"},{"key":"R8-20251013","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/2008-322X.163779","article-title":"Optic nerve aplsia: Case report and literature review","volume":"10","author":"Ghassemi","year":"2015","journal-title":"J Ophthalmic Vis Res"},{"key":"R9-20251013","first-page":"2072","article-title":"Non-syndromic bilateral and unilateral optic nerve aplasia: First familial occurrence and potential implication of CYP26A1 and CYP26C1 genes","volume":"17","author":"Meire","year":"2011","journal-title":"Mol Vis"},{"key":"R10-20251013","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4103\/0974-9233.134690","article-title":"Bilateral optic nerve aplasia: A rare isolated central nervous system anomaly","volume":"21","author":"Khandgave","year":"2014","journal-title":"Middle East Afr J Ophthalmol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223307-201866050-00032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:30:08Z","timestamp":1787758208000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223307-201866050-00032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_1108_17","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"2017-11-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}