{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:30:42Z","timestamp":1787758242819,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>Coronavirus disease 2019 (COVID-19) vaccinations have been associated with a higher risk of thromboembolic events. There have been no reports of central retinal artery occlusion (CRAO) after vaccination with the indigenously developed Covaxin, and worldwide, there has been only one such isolated case after administration of the AstraZeneca vaccine. We report a case of a 44-year-old healthy man who presented with sudden painless vision loss in his left eye 10 days after receiving Covaxin. His best-corrected visual acuity was minimal perception of light, with a relative afferent pupillary defect. Fundus examination revealed arterial attenuation and macular cherry red spot, suggesting an acute CRAO. Optical coherence tomography showed macular swelling and disorganization of the inner layers due to ischemic sequelae. Blood work was normal and cardiovascular examination was unremarkable. The patient was kept on follow-up. To our knowledge, this is the first case of an isolated CRAO after Covaxin administration, but further studies are needed to evaluate this potential association.<\/jats:p>","DOI":"10.4103\/ijo.ijo_1148_22","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T11:10:13Z","timestamp":1665054613000},"page":"3716-3719","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Central retinal artery occlusion after vaccination with whole virion inactivated SARSCoV- 2 vaccine Covaxin"],"prefix":"10.4103","volume":"70","author":[{"given":"Meenakshi","family":"Thakar","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"n1114","DOI":"10.1136\/bmj.n1114","article-title":"Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdO\u00d71-S in Denmark and Norway: Population based cohort study","volume":"373","author":"Potteg\u00e5rd","year":"2021","journal-title":"BMJ"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/S0140-6736(21)02000-6","article-title":"COVAXIN Study Group. Efficacy, safety, and lot-to-lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): Interim results of a randomised, double-blind, controlled, phase 3 trial","volume":"398","author":"Ella","year":"2021","journal-title":"Lancet"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"101430","DOI":"10.1016\/j.ajoc.2022.101430","article-title":"Central retinal artery occlusion following COVID-19 vaccine administration","volume":"26","author":"Abdin","year":"2022","journal-title":"Am J Ophthalmol Case Rep"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3390\/vaccines9111349","article-title":"Retinal vascular events after mRNA and adenoviral-vectored COVID-19 vaccines\u2014A case series","volume":"9","author":"Girbardt","year":"2021","journal-title":"Vaccines"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1093\/qjmed\/hcab287","article-title":"Combined central retinal artery and vein occlusion shortly after mRNA-SARS-CoV-2 vaccination","volume":"114","author":"Ikegami","year":"2022","journal-title":"QJM"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"2100956","DOI":"10.1183\/13993003.00956-2021","article-title":"Vaccination against COVID-19: Insight from arterial and venous thrombosis occurrence using data from VigiBase","volume":"58","author":"Smadja","year":"2021","journal-title":"Eur Respir J"},{"key":"B7-20240828","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1001\/jamaophthalmol.2021.3483","article-title":"COVID-19, COVID-19 vaccinations, and subsequent abnormalities in the retina: Causation or coincidence?","volume":"139","author":"Jampol","year":"2021","journal-title":"JAMA Ophthalmol"},{"key":"B8-20240828","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1001\/jamaophthalmol.2021.3477","article-title":"Association of ocular adverse events with inactivated COVID-19 vaccination in patients in Abu Dhabi","volume":"139","author":"Pichi","year":"2021","journal-title":"JAMA Ophthalmol"},{"key":"B9-20240828","doi-asserted-by":"crossref","first-page":"308","DOI":"10.4103\/ijo.IJO_1757_21","article-title":"Central retinal vein occlusion post-COVID-19 vaccination","volume":"70","author":"Sonawane","year":"2022","journal-title":"Indian J Ophthalmol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_1148_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:10:32Z","timestamp":1787757032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_1148_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":9,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_1148_22","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,30]]},"assertion":[{"value":"2022-05-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}