{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:28:45Z","timestamp":1786649325880,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To determine correlation and agreement between intraocular pressure (IOP) peak and fluctuations detected by day diurnal variation (day DVT) to that after the water-drinking test (WDT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients (18\u201380 years) with glaucoma, suspects, and ocular hypertension (OHT) were enrolled. IOP readings were taken on applanation tonometer, at 2-h intervals, from 8 AM to 3 PM (DVT). 3 PM IOP served as WDT baseline. Patients consumed water (10 mL\/kg) in 5\u201315 min, at 3 PM, after they fluid fasted for 2 h. IOP was recorded every 15 min, from 3.30 to 4.30 PM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 200 eyes (100 patients) were included. 58.5% were established glaucoma, 32% suspects, 9.5% OHT. Correlation between mean and peak IOP by WDT and day DVT was strong and significant (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.89,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.00;\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.73,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.00) while it was weak for fluctuation (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.12,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.07). Agreement on Bland and Altman plots was limited for mean IOP and poor for peak and fluctuations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>An exaggerated WDT response may indicate a compromised outflow facility and warrant close patient monitoring but the WDT cannot substitute day DVT in our clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1149_20","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T10:42:08Z","timestamp":1622630528000},"page":"1414-1417","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of intraocular pressure variability detected by day diurnal variation to that evoked by water drinking"],"prefix":"10.4103","volume":"69","author":[{"given":"Sujatha V","family":"Kadambi","sequence":"first","affiliation":[{"name":"Smt. Jadhavbai Nathmal Singhvee Glaucoma Services, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantha","family":"Balekudaru","sequence":"additional","affiliation":[{"name":"Smt. Jadhavbai Nathmal Singhvee Glaucoma Services, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya","family":"Lingam","sequence":"additional","affiliation":[{"name":"Smt. Jadhavbai Nathmal Singhvee Glaucoma Services, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"George","sequence":"additional","affiliation":[{"name":"Smt. Jadhavbai Nathmal Singhvee Glaucoma Services, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"key":"R1-20251004","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of intraocular pressure and glaucoma progression: Results from the early manifest glaucoma trial","volume":"120","author":"Heijl","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"R2-20251004","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1016\/j.ophtha.2011.01.047","article-title":"Intraocular pressure control and long-term visual field loss in the Collaborative initial glaucoma treatment study","volume":"118","author":"Musch","year":"2011","journal-title":"Ophthalmology"},{"key":"R3-20251004","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.ophtha.2007.03.016","article-title":"Predictors of long-term progression in the early manifest glaucoma trial","volume":"114","author":"Leske","year":"2007","journal-title":"Ophthalmology"},{"key":"R4-20251004","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00061198-200004000-00002","article-title":"Large diurnal fluctuations in intraocular pressure are an independent risk factor in patients with glaucoma","volume":"9","author":"Asrani","year":"2000","journal-title":"J Glaucoma"},{"key":"R5-20251004","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1001\/archopht.124.6.793","article-title":"Clinical utility of intraocular pressure monitoring outside of normal office hours in patients with glaucoma","volume":"124","author":"Barkana","year":"2006","journal-title":"Arch Ophthalmol"},{"key":"R6-20251004","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/bjo.58.1.55","article-title":"Inadequate diagnostic value of the water-drinking test","volume":"58","author":"Roth","year":"1974","journal-title":"Br J Ophthalmol"},{"key":"R7-20251004","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/ceo.12718","article-title":"Water drinking test: New applications","volume":"44","author":"Clement","year":"2016","journal-title":"Clin Exp Ophthalmol"},{"key":"R8-20251004","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/ceo.12503","article-title":"Challenging glaucoma with a water-drinking test","volume":"43","author":"Landers","year":"2015","journal-title":"Clin Exp Ophthalmol"},{"key":"R9-20251004","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/ceo.12925","article-title":"Applications of the water drinking test in glaucoma management","volume":"45","author":"Susanna","year":"2017","journal-title":"Clin Exp Ophthalmol"},{"key":"R10-20251004","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1442-9071.2008.01765.x","article-title":"Does peak intraocular pressure measured by water drinking test reflect peak circadian levels? 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