{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:52:48Z","timestamp":1788623568783,"version":"build-2803163510"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Cycloplegic refraction is mandatory for children to know the eye's refractive status. In this study, we compared cycloplegia induced by cyclopentolate 1% to that induced by atropine 1% by means of retinoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this parallel-designed interventional study, we included 67 children aged between 4 and 17 years. After the initial retinoscopy under cyclopentolate 1% (used twice in each eye), we repeated it a week later under atropine ointment 1% (used twice a day for 3 days); both were done by the same trained optometrist masked to the drug. Each eye's refraction was converted to spherical equivalents (SEs), and the values averaged between the two eyes of each child under each drug. We compared SE with paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test (JASP 16.4). In addition, we performed correlational analysis, and looked for agreement using the Bland\u2013Altman plot. Significance was set at\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05. Wherever possible, 95% confidence intervals (CIs) are quoted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean SE with atropine was +1.93 \u00b1 2.0 D, compared to +1.75 \u00b1 1.95 D under cyclopentolate. On average, atropine induced greater cycloplegia by a mere 0.18 D (95% CI: 0.07 to 0.29 D,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value 0.002). The two cycloplegic refractions correlated significantly (Pearson's\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      : 0.975,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The Bland\u2013Altman plot revealed the limits of agreement as 1.06 and \u22120.71 D.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study suggests that cyclopentolate works for the most part as well as atropine to attain cycloplegia. Atropine may be considered for children less than 15 years of age with greater than 5.0 D of hyperopia. Cycloplentolate, with its advantages of quick action and short duration, should form the first go-to topical cycloplegic in busy outpatient clinics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1159_23","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:01:08Z","timestamp":1700438468000},"page":"3633-3636","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of cycloplegia with atropine 1% versus cyclopentolate 1%"],"prefix":"10.4103","volume":"71","author":[{"given":"Ram P","family":"Singh","sequence":"first","affiliation":[{"name":"Institute of Ophthalmology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abadan K","family":"Amitava","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Sharma","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed A","family":"Raza","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Bose","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganga S","family":"Meena","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"R1-20260511","doi-asserted-by":"crossref","first-page":"e0167628","DOI":"10.1371\/journal.pone.0167628","article-title":"Pre- and postcycloplegic refractions in children and adolescents","volume":"11","author":"Zhu","year":"2016","journal-title":"PLoS One"},{"key":"R2-20260511","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/09273972.2019.1629466","article-title":"A randomized clinical trial using atropine, cyclopentolate, and tropicamide to compare refractive outcome in hypermetropic children with a dark iris; skin pigmentation and crying as significant factors for hypermetropic outcome","volume":"27","author":"van Minderhout","year":"2019","journal-title":"Strabismus"},{"key":"R3-20260511","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1755-3768.1988.tb04069.x","article-title":"Status of cyclopentolate as a cycloplegic in children: A comparison with atropine and homatropine","volume":"66","author":"Khurana","year":"1988","journal-title":"Acta Ophthalmol"},{"key":"R4-20260511","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4103\/0300-1652.184065","article-title":"Cycloplegic effect of atropine compared with cyclopentolate-tropicamide combination in children with hypermetropia","volume":"57","author":"Sani","year":"2016","journal-title":"Niger Med J"},{"key":"R5-20260511","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10384-018-0612-7","article-title":"Incidence of side effects of topical atropine sulfate and cyclopentolate hydrochloride for cycloplegia in Japanese children: A multicenter study","volume":"62","author":"Wakayama","year":"2018","journal-title":"Jpn J Ophthalmol"},{"key":"R6-20260511","first-page":"25","article-title":"Reverse amblyopia with atropine treatment","volume":"24","author":"Hainline","year":"2009","journal-title":"Binocul Vis Strabismus Q"},{"key":"R7-20260511","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.18240\/ijo.2021.07.14","article-title":"Lag of accommodation predicts clinically significant change of spherical equivalents after cycloplegia","volume":"14","author":"Jin","year":"2021","journal-title":"Int J Ophthalmol"},{"key":"R8-20260511","doi-asserted-by":"crossref","first-page":"228","DOI":"10.5935\/0004-2749.20140059","article-title":"Effects of 1% cyclopentolate hydrochloride on anterior segment parameters obtained with Pentacam in young adults","volume":"77","author":"Arici","year":"2014","journal-title":"Arq Bras Oftalmol"},{"key":"R9-20260511","article-title":"JASP (Version 0.14.6)[Computer software]","year":"2022"},{"key":"R10-20260511","article-title":"MedCalc Statistical Software version 20.210 (MedCalc Software bv, Ostend, Belgium","year":"2022"},{"key":"R11-20260511","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/cxo.13128","article-title":"Comparisons of atropine versus cyclopentolate cycloplegia in myopic children","volume":"104","author":"Ye","year":"2021","journal-title":"Clin Exp Optom"},{"key":"R12-20260511","year":"2022","journal-title":"[Internet]"},{"key":"R13-20260511","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1034\/j.1600-0420.1999.770414.x","article-title":"The comparison of cyclopentolate and atropine in patients with refractive accommodative esotropia by means of retinoscopy, autorefractometry and biometric lens thickness","volume":"77","author":"\u00c7elebi","year":"1999","journal-title":"Acta Ophthalmol Scand"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_1159_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:28:09Z","timestamp":1786724889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_1159_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_1159_23","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,20]]},"assertion":[{"value":"2023-05-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}