{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:29:59Z","timestamp":1787758199200,"version":"build-2784847793"},"reference-count":2,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>Dry eye syndrome (DES) is a common disorder with rising incidence due to increased use of digital devices. While multiple treatment options are available, some are not efficacious or sometimes even safe for use in DES. This is particularly true for Fixed Dose Combinations (FDCs) that may contain ingredients having no rational for their use or may actually be harmful. Various committees appointed by the Government have reviewed several FDCs marketed in India and found some of them to be irrational and recommended for their removal. This paper discusses the contents of some of these FDCs marketed for DES with an aim to ensure that prescribers are mindful of their ingredients and whether there is adequate data about their efficacy and safety and prescribe them only if they consider them necessary for managing the patient.<\/jats:p>","DOI":"10.4103\/ijo.ijo_1169_22","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T11:10:13Z","timestamp":1665054613000},"page":"3687-3689","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Irrational ophthalmic fixed-dose combinations for dry eye syndrome"],"prefix":"10.4103","volume":"70","author":[{"given":"Nilima A","family":"Kshirsagar","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Emeritus Scientist, ICMR, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renuka","family":"Munshi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, TN Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep B","family":"Bavdekar","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Surya Children\u2019s Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Saxena","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology and Strabismus Services, Dr. R. P. Centre for Ophthalmic Sciences, AIIMS, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/704946","article-title":"Comprehensive review on dry eye disease: Diagnosis, medical management, recent developments and future challenges","author":"Phadatare","year":"2015","journal-title":"Advances in Pharmaceutics"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1007\/s00417-020-04808-3","article-title":"Dry eye in the COVID-19 era: How the measures for controlling pandemic might harm ocular surface","volume":"258","author":"Giannaccare","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_1169_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:10:17Z","timestamp":1787757017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_1169_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":2,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_1169_22","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,30]]},"assertion":[{"value":"2022-05-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}