{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:23:07Z","timestamp":1787844187264,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Evaluation of circumpapillary vessel density (VD) and perfusion density (PD) on optical coherence tomography angiography (OCTa) in mild-moderate glaucoma patients having unilateral visual field defects, with their fellow eyes and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Both eyes of 24 patients having a definitive nasal step or arcuate scotoma in one hemisphere of one eye only, and 24 controls, underwent OCTa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In eyes with a superior field defect, the superior\/inferior quadrant ratios, (SQ\/IQ) of 3 mm scan of VD and PD were significantly higher in eyes with a superior arcuate scotoma than fellow eyes (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03,0.02) as also controls, (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004,0.001). The mean percentage loss of inferior quadrant VD between control to fellow eyes, and superior nasal step eyes were similar, 20.19%\/19.57% respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.85, while a loss in arcuate scotoma eyes was 38.81% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). The percentage decrease in inferior quadrant PD in fellow eyes was 14.70%, superior nasal step 23.39%, and an arcuate scotoma 34.74% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02). Eyes with a superior nasal step had significantly lower VD and PD absolute values in the inferior quadrant OCTa in 3 mm and 6 mm circle scan only as compared to control eyes, VD,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03,0.04\/PD,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.008,0.02. Fellow eyes of superior field defects had significantly lower VD and PD absolute values in the inferior quadrant in 3 mm and 6 mm circle scan as compared to control eyes, VD,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.006,0.04\/PD,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01,0.03. Eyes with an isolated inferior field defect in only one eye, showed a significant decrease in both VD and PD in all quadrants as compared to fellow eyes and control eyes. A significant positive correlation was found between VD and RNFL thickness in peripapillary superior unaffected quadrants in eyes with superior field defects and inferior unaffected quadrants in inferior defects (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001 and 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There was a statistically significant increasing SQ\/IQ ratio and percentage loss of vascular parameters from control to fellow eyes, those with a superior nasal step, and those with a superior arcuate scotoma. Inferior VFDs appeared to be associated with a more generalized circulatory loss. The asymmetry between hemispheres and between eyes could be used as a biomarker for early glaucomatous neuropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1191_20","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T11:32:28Z","timestamp":1619955148000},"page":"1120-1126","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Circumpapillary optical coherence tomography angiography differences in perimetrically affected and unaffected hemispheres in primary open-angle glaucoma and the preperimetric fellow eye"],"prefix":"10.4103","volume":"69","author":[{"given":"Ramanjit","family":"Sihota","sequence":"first","affiliation":[{"name":"Glaucoma Service, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 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