{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:12Z","timestamp":1786649832099,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2]]},"abstract":"\n Genome-wide association studies (GWAS) have identified that single-nucleotide polymorphisms (SNPs) rs1258267 in\n CHAT<\/jats:italic>\n and rs3753841 in\n COL11A1<\/jats:italic>\n are associated with primary angle-closure glaucoma (PACG). The purpose of the study was to evaluate the association of\n CHAT<\/jats:italic>\n rs1258267 and\n COL11A1<\/jats:italic>\n rs3753841 with PACG. A comprehensive electronic database search was performed to include eligible studies, published from October 2010 to March 2022. By calculating summary odds ratios (ORs) and 95% confidence intervals (CI) under five genetic models, the risk of PACG related to these two SNPs could be estimated. Heterogeneity was measured with a Chi-square-based\n Q<\/jats:italic>\n statistic test and the\n I2<\/jats:italic>\n statistic. By the\n Z<\/jats:italic>\n test, we analyzed the overall effect of OR. We used funnel plots and Begg\u2019s funnel plots to evaluate the publication bias of included studies. The meta-analysis was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 checklist. There were eighteen studies associating\n CHAT<\/jats:italic>\n rs1258267 with PACG indicating evidently decreased PACG risk in five genetic models. Thirty studies were included to demonstrate a notable increase in the risk of PACG-carrying\n COL11A1<\/jats:italic>\n rs3753841 genotypes. Subgroup analyses showed that the association of\n CHAT<\/jats:italic>\n rs1258267 and\n COL11A1<\/jats:italic>\n rs3753841 with PACG was obvious in Asians, while no evidence was found to confirm this connection in Caucasians. This meta-analysis suggests that\n CHAT<\/jats:italic>\n rs1258267 G\/A polymorphisms could bring about a decreased risk of PACG susceptibility and\n COL11A1<\/jats:italic>\n rs3753841 G\/A polymorphisms could cause an increased risk. These effects mainly manifest in Asians.\n <\/jats:p>","DOI":"10.4103\/ijo.ijo_1226_22","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T09:22:50Z","timestamp":1675329770000},"page":"343-349","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Genetic associations in CHAT and COL11A1 with primary angle-closure glaucoma susceptibility: A systematic review and meta-analysis"],"prefix":"10.4103","volume":"71","author":[{"given":"Shaowen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Eye Institute, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye Institute, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, 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