{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:10:11Z","timestamp":1793214611564,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To describe the clinical course and treatment outcomes of Vogt\u2013Koyanagi\u2013Harada (VKH) disease during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study compares the clinical course and outcomes in pregnant and nonpregnant women with VKH. All VKH patients who were pregnant at presentation or on follow up and age-matched nonpregnant female controls during the study period (2013\u20132022) were included. Their best-corrected visual acuity (BCVA), clinical presentations, and treatment outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among the 532 female VKH patients, nine (1.7%) were included. Thirty nonpregnant patients were included as control. At presentation, the mean age in the study group was 26 years \u00b1 6.48 standard deviation (SD) compared to the control group (mean 25.1 years \u00b1 3.04). The mean BCVA was comparable between the two groups at presentation (study group 1.35 logarithm of the minimum angle of resolution [logMAR] vs. control group 0.76 logMAR;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.05) and the final follow-up (study group 0.65 logMAR vs. control group 0.35 logMAR;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.15). Participants with anterior segment inflammation (study group 77.7% vs. control group 70%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.65), the disease stage (early-stage VKH: study group 88.8% vs. control group 73.3%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.33), and disease exacerbation (study group 33.3% vs. control group 26.6%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.69) were all comparable between the study and control groups. Following treatment, 66.6% and 46.6% of the study and control groups, respectively, had sunset glow fundus (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.29). At the last follow-up, 44.4% and 26.6% of the study and control groups, respectively, had subretinal fibrosis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.31).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Though pregnancy is an immunomodulatory state, the clinical course of VKH in pregnant patients can be similar to that of nonpregnant women and needs close monitoring and follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1251_24","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T10:01:04Z","timestamp":1735034464000},"page":"S158-S163","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Effects of pregnancy on the clinical course and treatment outcomes of Vogt\u2013Koyanagi\u2013Harada disease"],"prefix":"10.4103","volume":"73","author":[{"given":"Navya","family":"Cherukuri","sequence":"first","affiliation":[{"name":"Smt. Kannuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India"},{"name":"Uveitis and Ocular Immunology Services, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somasheila I","family":"Murthy","sequence":"additional","affiliation":[{"name":"Uveitis and Ocular Immunology Services, Hyderabad, Telangana, India"},{"name":"Shantilal Shanghvi Cornea Institute, L V Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudit","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Smt. Kannuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India"},{"name":"Uveitis and Ocular Immunology Services, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"R1-20260424","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00055735-200012000-00009","article-title":"Vogt-Koyanagi-Harada disease","volume":"11","author":"Read","year":"2000","journal-title":"Curr Opin Ophthalmol"},{"key":"R2-20260424","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.humimm.2011.09.002","article-title":"Major histocompatibility complex and strong human leukocyte antigen-DRB1 and gender association with Vogt-Koyanagi-Harada syndrome in Mexican Mestizos","volume":"72","author":"Al\u00e1ez","year":"2011","journal-title":"Hum 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