{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T01:14:10Z","timestamp":1788052450061,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To report the preliminary experience and initial clinical results following SMILE for the treatment of mixed astigmatism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirteen eyes of nine patients with a mean age of 27 \u00b1 4.36 years were included in the series. In 8\/13 eyes, myopic SMILE license and in 4\/13 eyes, hyperopic SMILE license (available as part of an open\/research software) was used for the treatment. The mean follow-up was 9.5 \u00b1 8.7 (0.5\u201324) months, and the median follow-up was 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Nethradhama Superspeciality Eye Hospital, Bangalore, India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Exploratory study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean preoperative sphere, cylinder, and spherical equivalent (SE) were 1.44 \u00b1 1.63, \u22122.70 \u00b1 2.30, and \u22120.24 \u00b1 1.14 D, which changed to \u22120.03 \u00b1 0.30, \u22120.28 \u00b1 0.48, and \u22120.18 \u00b1 0.49 D, respectively, 6 months postoperatively. Furthermore, 85% (11\/13) eyes were within \u00b1 0.50 D, 92% (12\/13) eyes were within \u00b1 1.00 D, while all eyes were within \u00b1 1.50 D of SE correction. All eyes were within \u00b1 1.00 D of cylinder correction. In addition, 92% (12\/13) eyes had UDVA better than 20\/32, with 54% (7\/13) eyes having UDVA 20\/20 or better. Safety and efficacy indices were 1.08 and 0.92, respectively. No eyes lost more than 1 line of CDVA. The mean corneal higher order aberrations (HOA) increased from 0.111 \u00b1 0.048 to 0.209 \u00b1 0.056 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The mean objective scatter index (OSI) did not show a significant change (pre = 0.71 \u00b1 0.69, 6 months = 0.89 \u00b1 0.20;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.35).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early experience showed that SMILE was feasible for the management of eyes with mixed astigmatism, without any intraoperative complications, unique to the procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1273_23","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T15:09:29Z","timestamp":1718982569000},"page":"1056-1063","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Feasibility study of treatment of mixed astigmatism with small-incision lenticule 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