{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:21:07Z","timestamp":1787761267336,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To study the safety and efficacy outcomes of Micropulse Transscleral Cyclophotocoagulation (MP-TSCPC) as a primary versus additional therapy in eyes with uncontrolled glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a prospective, interventional, comparative study. All patients with advanced and refractory glaucoma treated with MP-TSCPC from April 2020 to December 2020 were recruited in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 77 eyes of 77 patients were analyzed. Group A (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 33), included patients with advanced glaucoma at high risk for invasive surgery, who underwent MP-TSCPC as the primary intervention, and group B (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 44) included patients who had undergone previous surgical intervention and MP-TSCPC was used additionally to control the intraocular pressure (IOP). Mean IOP and mean number of antiglaucoma medications were 34.06 (13.9) mmHg and 3.64 (0.7), respectively, in group A and 35.61 (11.5) mmHg and 3.73 (0.9), respectively, in Group B. Postoperatively, the mean IOP and percentage of IOP reduction were significantly lower at 1, 3, and 6 months, that is, 20.78 (32%), 22.07 (30%), and 19.09 (37%), respectively, in group A and 23.68 (35%), 19.50 (44%), and 19.61 (42%), respectively, in group B, but there was no difference between the groups at all visits. Postoperative need for ocular hypotensive drugs did not differ in group A (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.231); however, it was significantly lower in group B (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.027). Group A had 87%, 77%, and 74% success rates at 1, 3, and 6 months, respectively, whereas group B had 91%, 86%, and 77% success rates at 1, 3, and 6 months, respectively. Postoperative complications and intervention did not reveal any statistical difference between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MP-TSCPC may be considered as a temporizing measure both as a primary or as an additional intervention to control the IOP in eyes with refractory and advanced glaucoma that have a high risk of vision-threatening complications with invasive surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1289_22","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T09:14:27Z","timestamp":1672910067000},"page":"140-145","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Short-term outcomes of micropulse transscleral cyclophotocoagulation as a primary versus additional therapy in eyes with uncontrolled glaucoma"],"prefix":"10.4103","volume":"71","author":[{"given":"Sharmila","family":"Rajendrababu","sequence":"first","affiliation":[{"name":"Department of Glaucoma, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayalakshmi A","family":"Senthilkumar","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Techi Dodum","family":"Tara","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Sithiq","family":"Uduman","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxmi Ananya","family":"Aila","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aakriti Garg","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Wills Eye Hospital, Glaucoma Services, Philadelphia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/bjo.80.5.389","article-title":"Number of people with glaucoma worldwide","volume":"80","author":"Quigley","year":"1996","journal-title":"Br J Ophthalmol"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"e879","DOI":"10.1097\/IJG.0000000000000490","article-title":"Additive effect of risk factors for trabeculectomy failure in glaucoma patients:A risk-group from a cohort study","volume":"25","author":"Issa de Fendi","year":"2016","journal-title":"J Glaucoma"},{"key":"R3-20240828","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00004397-198102110-00012","article-title":"Cyclocryotherapy for glaucoma","volume":"21","author":"Bellows","year":"1981","journal-title":"Int Ophthalmol Clin"},{"key":"R4-20240828","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/S0161-6420(96)30508-3","article-title":"Long-term outcome of initial ciliary ablation with contact diode laser transscleral cyclophotocoagulation for severe glaucoma. 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