{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:11Z","timestamp":1786649891460,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the impact of different-thickness scleral lenses (SLs) on corneal thickness, curvature, and fluid reservoir thickness in keratoconic eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Schiempflug imaging and AS-OCT was captured before and immediately following 6 h of SL wear. Different-thickness lenses were used while keeping the other parameters the same. The timing of the measurement for day 1 and day 2 was matched to allow for the control of the confounding influence of diurnal variation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Immediately after 6 h of lens wear, no statistically significant difference (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05) was noted in corneal edema in any region and quadrants between thin- and thick-lens wearers. The calculated percentage of corneal edema was also within the range of overnight closed eye physiological swelling. Pentacam measured higher central corneal thickness compared to AS-OCT in both baselines and after 6 h of lens wear. The current investigation reported minimal but not statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05) flattening in anterior and steepening in posterior curvature parameters in both thin and thick SLs. The mean reduction in the fluid reservoir thickness was 80.00 \u00b1 3.99 and 79.36 \u00b1 3.84 microns after 6 h of thin- and thick-lens wear, respectively, which was not statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). A statistically significant positive correlation (r = 0.67,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02) was found between lens thickness and change in anterior steep k with thick-lens wear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Central lens thickness of 200\u2013400 mm did not cause any significant change in corneal curvature and fluid reservoir thickness and did not induce clinically significant corneal edema after short-term SL wear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1309_22","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T08:53:31Z","timestamp":1670316811000},"page":"4251-4256","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["The effect of different thickness scleral lens on corneal parameters in eyes with keratoconus"],"prefix":"10.4103","volume":"70","author":[{"given":"Asif","family":"Iqbal","sequence":"first","affiliation":[{"name":"Department of Contact Lens, Sankara Nethralaya, Unit of Medical Research Foundation, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinu","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Contact Lens, Sankara Nethralaya, Unit of Medical Research Foundation, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeswari","family":"Mahadevan","sequence":"additional","affiliation":[{"name":"Department of Contact Lens, Sankara Nethralaya, Unit of Medical Research Foundation, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/01.icl.0000233217.68379.d5","article-title":"Modern scleral lenses part I:Clinical features","volume":"33","author":"Visser","year":"2007","journal-title":"Eye Contact Lens"},{"key":"R3-20251006","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1136\/bjo.80.12.1068","article-title":"Diurnal variations in human corneal thickness","volume":"80","author":"Harper","year":"1996","journal-title":"Br J Ophthalmolo"},{"key":"R4-20251006","first-page":"211","article-title":"Overnight swelling of the living human cornea","volume":"51","author":"Mertz","year":"1980","journal-title":"J Am Optom Assoc"},{"key":"R5-20251006","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0141-7037(88)80006-5","article-title":"Corneal response to gas-permeable impression scleral lenses","volume":"11","author":"Bleshoy","year":"1988","journal-title":"J Br Contact Lens Assoc"},{"key":"R6-20251006","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1167\/iovs.05-0234","article-title":"Recording three-dimensional eye movements:Scleral search coils versus video oculography","volume":"47","author":"Houben","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R7-20251006","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.clae.2014.08.002","article-title":"Corneal changes following short-term mini scleral contact lens wear","volume":"37","author":"Vincent","year":"2014","journal-title":"Cont Lens Anterior Eye"},{"key":"R8-20251006","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.clae.2015.03.006","article-title":"Scleral lens influence on corneal curvature and pachymetry in keratoconus patients","volume":"38","author":"Soeters","year":"2015","journal-title":"Cont Lens Anterior Eye"},{"key":"R9-20251006","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1097\/OPX.0000000000000409","article-title":"A comparison of the short-term settling of three scleral lens designs","volume":"91","author":"Kauffman","year":"2014","journal-title":"Optom Vis Sci"},{"key":"R10-20251006","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clae.2017.03.008","article-title":"Change in vault during scleral lens trials assessed with anterior segment optical coherence tomography","volume":"40","author":"Rathi","year":"2017","journal-title":"Cont Lens Anterior Eye"},{"key":"R11-20251006","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.clae.2007.03.001","article-title":"Collaborative longitudinal evaluation of keratoconus (CLEK) study group. 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