{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:25:56Z","timestamp":1789525556262,"version":"build-2803163510"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study aims to assess the impact of polycythemia vera (PV) on retinal and optic nerve head (ONH) vessel density (VD) parameters, macular ganglion cell complex (mGCC) thickness, and retinal nerve fiber layer (RNFL) thickness compared to healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty eyes of 20 patients with PV and 40 eyes of 20 age-gender-matched healthy controls underwent comprehensive ophthalmologic assessments and optic coherence tomography angiography (OCTA). RNFL and macular GCC measurements were obtained simultaneously with vascular parameters by AngioVue OCTA using the single-scan protocol. Peripapillary VD was examined across eight sectors, whereas parameters including RNFL, GCC, and macular VD were analyzed in four quadrants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Patients with PV exhibited significant reductions in the average RNFL thickness (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.014) and RNFL thickness in superior (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and inferior (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003) quadrants compared to controls. Additionally, mGCC thickness in all quadrants significantly reduced in the PV group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). ONH VD parameters, including whole-image VD (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and peripapillary VD (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), were significantly reduced in patients with PV. Similarly, macular VD parameters were significantly lower in the PV group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study highlights substantial vascular and structural alterations in the retina and ONH of patients with PV compared to healthy controls. These changes likely stem from microvascular dysfunction associated with PV. These findings suggest further research to understand the underlying mechanisms and develop targeted therapeutic strategies for managing ocular complications in patients with PV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1322_24","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T03:02:14Z","timestamp":1726023734000},"page":"S863-S869","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Evaluating the impact of polycythemia vera on retinal and optic nerve head microvascularity: An OCTA study"],"prefix":"10.4103","volume":"72","author":[{"given":"Meryem Feyza","family":"Cicek","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hassa State Hospital, Hatay, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turker","family":"Oba","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Karaman Training and Research Hospital, Karaman, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"A\u011f\u0131n","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mesut","family":"Ayer","sequence":"additional","affiliation":[{"name":"Department of Hematology, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza","family":"Onder","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"R1-20260426","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1182\/blood-2014-02-554634","article-title":"Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis","volume":"123","author":"Rampal","year":"2014","journal-title":"Blood"},{"key":"R2-20260426","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s11739-010-0369-6","article-title":"Polycythemia vera","volume":"5","author":"Landolfi","year":"2010","journal-title":"Intern Emerg Med"},{"key":"R3-20260426","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1182\/blood-2006-10-048298","article-title":"Increased adhesion to endothelial cells of erythrocytes from patients with polycythemia vera is mediated by laminin alpha5 chain and Lu\/BCAM","volume":"110","author":"Wautier","year":"2007","journal-title":"Blood"},{"key":"R4-20260426","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4103\/ojo.OJO_110_2014","article-title":"Polycythemia causing posterior segment vascular occlusions","volume":"10","author":"Ganesan","year":"2017","journal-title":"Oman J Ophthalmol"},{"key":"R5-20260426","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/ICB.0000000000000114","article-title":"Jak2 mutation-positive polycythemia vera presenting as central retinal artery occlusion","volume":"9","author":"Dhrami-Gavazi","year":"2015","journal-title":"Retin Cases Brief Rep"},{"key":"R6-20260426","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0002-9394(55)91281-2","article-title":"New theories of vascular disease; With special reference to the syndrome of polycythemia in ocular pathology","volume":"39","author":"Birge","year":"1955","journal-title":"Am J Ophthalmol"},{"key":"R7-20260426","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000114890","article-title":"Polycythemia vera and transient monocular blindness. 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