{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:23:25Z","timestamp":1788355405996,"version":"build-2803163510"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study aimed to review the demographics, clinical characteristics, and long-term outcomes of therapeutic penetrating keratoplasty (TPK) performed in a tertiary eye care hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Case records of 149 therapeutic transplants (135 patients) that were performed during the calendar year 2016 were retrospectively analyzed, and outcomes were measured until 3 years of follow-up. Information on demographics, presentation characteristics, keratoplasty indications, offending microbe, and secondary surgical interventions was studied. The final outcome was classified in terms of therapeutic, anatomical, and functional outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The median age of the recipients was 55 years with 61% men. The most common indications for TPK were perforated infectious ulcer (45.9%), nonhealing ulcers (29.9%), and graft infections (17.4%). Fungal etiology was noted in 61.2% and bacterial etiology in 17.4% of the eyes. Therapeutic success was achieved in 130 eyes (89%) at the end of 1 month. Anatomical success was achieved in 130 (98.5%) and 88 patients (86.3%) at the end of 1 and 6 months, respectively. At the 6-month time point, 78 patients (76.5%) attained functional success with vision better than light perception. Three-year follow-up data were available for 23.7% of recipients, of which only 12 patients (37.5%) retained a clear graft either after a primary therapeutic or secondary optical keratoplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Therapeutic keratoplasty is highly effective in eradicating infection and providing anatomical integrity. However, timely intervention can aid in achieving the best functional outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1344_23","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T07:55:56Z","timestamp":1692604556000},"page":"3171-3177","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Long-term outcomes of therapeutic corneal transplants performed in a tertiary eye care hospital in South India"],"prefix":"10.4103","volume":"71","author":[{"given":"Josephine S","family":"Christy","sequence":"first","affiliation":[{"name":"Cornea and Refractive Services, Aravind Eye Hospital, Pondicherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Mathews","sequence":"additional","affiliation":[{"name":"Cornea and External Diseases Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmita","family":"Ravisankar","sequence":"additional","affiliation":[{"name":"Cornea and Refractive Services, Aravind Eye Hospital, Pondicherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esen K","family":"Akpek","sequence":"additional","affiliation":[{"name":"Cornea and External Diseases Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"R1-20251008","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4103\/0970-0218.120153","article-title":"Burden of corneal blindness in India","volume":"38","author":"Gupta","year":"2013","journal-title":"Indian J Community Med"},{"key":"R2-20251008","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/ijo.IJO_862_16","article-title":"Upgradation 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analysis","volume":"32","author":"Rogers","year":"2013","journal-title":"Cornea"},{"key":"R9-20251008","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.joco.2018.04.001","article-title":"Outcome of therapeutic penetrating keratoplasty in advanced infectious keratitis","volume":"30","author":"Raj","year":"2018","journal-title":"J Curr Ophthalmol"},{"key":"R10-20251008","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.2147\/OPTH.S92176","article-title":"Outcome of therapeutic penetrating keratoplasty in a tertiary eye care center in Nepal","volume":"9","author":"Bajracharya","year":"2015","journal-title":"Clin Ophthalmol"},{"key":"R11-20251008","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.2147\/IDR.S204025","article-title":"Outcomes of therapeutic keratoplasty for severe infectious keratitis in Chongqing, a 16-year experience","volume":"12","author":"Zhang","year":"2019","journal-title":"Infect Drug 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