{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:23:41Z","timestamp":1787847821056,"version":"build-2784847793"},"reference-count":67,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>The primary focus of this review was to establish the possible association of dysbiotic changes in the gut bacterial microbiomes with both intestinal and extra-intestinal diseases with emphasis on ocular diseases such as bacterial keratitis, fungal keratitis, uveitis, age-related macular degeneration, and ocular mucosal diseases. For this particular purpose, a systematic search was conducted using PubMed and Google Scholar for publications related to gut microbiome and human health (using the keywords: gut microbiome, ocular disease, dysbiosis, keratitis, uveitis, and AMD). The predictions are that microbiome studies would help to unravel dysbiotic changes in the gut bacterial microbiome at the taxonomic and functional level and thus form the basis to mitigate inflammatory diseases of the eye by using nutritional supplements or fecal microbiota transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1362_20","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T05:35:03Z","timestamp":1613540103000},"page":"535-542","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":33,"title":["A systematic review of gut microbiome and ocular inflammatory diseases"],"prefix":"10.4103","volume":"69","author":[{"given":"Sisinthy","family":"Shivaji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20240828","doi-asserted-by":"crossref","first-page":"e1002533)","DOI":"10.1371\/journal.pbio.1002533","article-title":"Revised estimates for the number of human and bacteria cells in the body","volume":"14","author":"Sender","year":"2016","journal-title":"PLoS Biol"},{"key":"R2-12-20240828","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"R3-12-20240828","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.3389\/fmicb.2018.01835","article-title":"The human gut microbiome \u2013 A potential controller of wellness and disease","volume":"9","author":"Kho","year":"2018","journal-title":"Front Microbiol"},{"key":"R4-12-20240828","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/icb.2009.71","article-title":"Gut commensal Lactobacillus reuteri 100-23 stimulates an immunoregulatory response","volume":"88","author":"Livingston","year":"2010","journal-title":"Immunol Cell Biol"},{"key":"R5-12-20240828","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/microorganisms7010014","article-title":"What is the healthy gut microbiota composition. 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