{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:29:55Z","timestamp":1787761795000,"version":"build-2784847793"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To examine the role of the strain ratio in elastosonography for the differential diagnosis of common intraocular tumors such as choroidal melanoma, choroidal hemangioma, choroidal metastatic carcinoma, and retinoblastoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study included patients suffering from intraocular space-occupying lesions and who visited Beijing Tongren Eye Center of Beijing Tongren Hospital affiliated to Capital Medical University from June 2016 to March 2020. All patients underwent a physical examination, fundus examination with mydriasis, color Doppler ultrasonography, elastosonography, magnetic resonance imaging (MRI), and fundus angiography within 1 week. All patients were grouped as choroidal melanoma, choroidal metastatic carcinoma, retinoblastoma, choroidal hemangioma, and optic disk melanocytoma. A receiver operating characteristic (ROC) curve analysis was performed to assess the strain ratio for diagnosing malignant intraocular tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 155 patients (161 eyes) were recruited. The strain ratios measured were 39.59 \u00b1 15.92 for choroidal melanoma, 36.85 \u00b1 13.64 for choroidal metastatic carcinoma, 38.93 \u00b1 17.27 for retinoblastoma, 13.42 \u00b1 10.93 for choroidal hemangioma, and 3.84 \u00b1 1.32 for optic disk melanocytoma. The strain ratios of the three malignant lesions were significantly higher than those of the two benign lesions (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The area under the ROC curve was 0.95 \u00b1 0.028. The optimal cutoff point was 22.67, with 85.7% sensitivity and 96.4% specificity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There were significant differences in elasticity between the malignant and benign intraocular tumors. The strain ratio using elastosonography could serve as an important auxiliary examination to distinguish between benign and malignant intraocular tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1397_22","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T06:19:36Z","timestamp":1678256376000},"page":"983-988","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Value of the strain ratio in the differential diagnosis of intraocular tumors by elastosonography: A retrospective case-control study"],"prefix":"10.4103","volume":"71","author":[{"given":"Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumour Diagnosis and Treatment, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Dongcheng District, 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