{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:15:13Z","timestamp":1792462513527,"version":"4.5.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To characterize the impact of neovascular glaucoma (NVG) and its underlying etiology on mortality and determine the association between NVG and cause of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>A total of 210 subjects with NVG were included in the descriptive study. Of the 210 subjects, 132 with a definite date of NVG onset were included in the survival analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients with NVG seen at our tertiary care center from 2015\u20132016 were identified. Demographic information, underlying etiology, and medical conditions were documented. The Centers for Disease Control and Prevention National Death Index (CDC NDI) was used to designate if subjects were alive on December 31, 2021, and to determine the primary cause of death. Kaplan-Meier and Cox proportional hazard regression analyses were performed on subjects with a definitive date of NVG onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 210 subjects, 32% were deceased by December 31, 2021. The commonest diagnosis was proliferative diabetic retinopathy (PDR) (57%), followed by central retinal vein occlusion (CRVO) (29%). Of 132 subjects included in the Kaplan-Meier survival analysis, the mean survival time was 154 \u00b1 15 months (95% CI: 125\u2013183). Cox regression analysis demonstrated that older age (HR 1.03, 95% CI: 1.004\u20131.06,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02) and central retinal artery occlusion (CRAO) (HR: 4.63, 95% CI: 1.7\u201312.44,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002) were associated with poorer survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Increasing age and CRAO-related NVG (compared to CRVO-unrelated) were important predictors of increased mortality. Our results highlight the need for aggressive management of underlying systemic co-morbid conditions contributing to early mortality in patients with NVG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1421_25","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T15:00:12Z","timestamp":1767020412000},"page":"81-86","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Mortality in neovascular glaucoma"],"prefix":"10.4103","volume":"74","author":[{"given":"Kirstyn C","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakshi","family":"Shiromani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avital L Okrent","family":"Smolar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Cijin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cincinnati Children\u2019s Hospital, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Kedar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepta A","family":"Ghate","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/08820530902800801","article-title":"Neovascular glaucoma: Etiology, diagnosis and prognosis","volume":"24","author":"Shazly","year":"2009","journal-title":"Semin Ophthalmol"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40942-016-0051-x","article-title":"Neovascular glaucoma: A review","volume":"2","author":"Rodrigues","year":"2016","journal-title":"Int J Retina Vitreous"},{"key":"R3-20260420","first-page":"24","article-title":"Neovascular secondary glaucoma, etiology and pathogenesis","volume":"59","author":"Barac","year":"2015","journal-title":"Romanian J 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Long-term results and factors influencing the outcome","volume":"100","author":"Mermoud","year":"1993","journal-title":"Ophthalmology"},{"key":"R19-20260420","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.oret.2016.09.002","article-title":"Long-term mortality in diabetic patients with tractional retinal detachments","volume":"1","author":"Shukla","year":"2017","journal-title":"Ophthalmol Retina"},{"key":"R20-20260420","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.3390\/jcm10143093","article-title":"Central and branch retinal artery occlusion\u2014Do they harbor the same risk of further ischemic events?","volume":"10","author":"Roskal-Wa\u0142ek","year":"2021","journal-title":"J Clin Med"},{"key":"R21-20260420","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3341\/kjo.2016.30.5.352","article-title":"Incidence and clinical features of neovascularization of the Iris following acute central retinal artery occlusion","volume":"30","author":"Jung","year":"2016","journal-title":"Korean J Ophthalmol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_1421_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:01:00Z","timestamp":1786647660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_1421_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_1421_25","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"2025-06-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}