{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:23Z","timestamp":1786649843050,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study was conducted to examine microbiological profile with their antibiotic sensitivity in cases of bacterial keratitis in north and central India to ensure appropriate use of antibiotics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The microbiology laboratory records of 228 patients with culture-proven bacterial keratitis from 1\n                      <jats:sup>st<\/jats:sup>\n                      January to 31\n                      <jats:sup>st<\/jats:sup>\n                      December 2019 were analyzed. Cultured bacterial isolates were subjected to antimicrobial susceptibility testing to antibiotics commonly used in the treatment of corneal ulcer. Chi-squared or Fisher\u2019s exact test were applied to check the significance of difference between the susceptibility levels of antibiotics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The prevalence of\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      \u2013induced keratitis was higher in northern India, whereas that by\n                      <jats:italic toggle=\"yes\">Streptococcus pneumoniae<\/jats:italic>\n                      was more prevalent in central India. In central India, 100% of\n                      <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                      isolates were found to be sensitive to ceftriaxone compared to 79% in northern India (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.017). In comparison to 67% of isolates from north India, 15% of\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      isolates from central India were found to be sensitive to ofloxacin (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.009). Similarly, 23% of isolates from central India were found sensitive to amikacin compared to 65% of isolates from north India (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.012).\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      isolates from central India were found to be sensitive to ceftazidime in 63% of cases compared to 21% of isolates from north India (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Prevalence of bacteria and their susceptibility to antibiotics are not uniform across geography. Vancomycin remained the most effective drug in all gram-positive coccal infections.\n                      <jats:italic toggle=\"yes\">S<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">aureus<\/jats:italic>\n                      susceptibility to amikacin was significantly greater in north India.\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      .\n                      <jats:italic toggle=\"yes\">aeruginosa<\/jats:italic>\n                      showed less susceptibility as compared to previous reports.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1438_22","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T08:53:31Z","timestamp":1670316811000},"page":"4263-4269","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Antibiotic susceptibility pattern of bacterial isolates from microbial keratitis in North and Central India: A multi centric study"],"prefix":"10.4103","volume":"70","author":[{"given":"Ashi","family":"Khurana","sequence":"first","affiliation":[{"name":"Department of Cornea and Anterior Segment Services, CL Gupta Eye Institute, Moradabad, Uttar Pradesh, India"},{"name":"The Bodhya Eye Consortium: a. Dr Shroff\u2019s Charity Eye Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samrat","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Cornea and Anterior Segment Services, MGM Eye Institute, Raipur, Chhattisgarh, India"},{"name":"The Bodhya Eye Consortium: a. Dr Shroff\u2019s Charity Eye Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpan","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Services, Dr Shroff\u2019s Charity Eye Hospital, New Delhi, India"},{"name":"The Bodhya Eye Consortium: a. Dr Shroff\u2019s Charity Eye Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Borde","sequence":"additional","affiliation":[{"name":"Department of Cornea and Refractive Services, Sadguru Netra Chikitsalaya, Jankikund, Chitrakoot, Uttar Pradesh, India"},{"name":"The Bodhya Eye Consortium: a. Dr Shroff\u2019s Charity Eye Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Chanda","sequence":"additional","affiliation":[{"name":"Department of Cornea and Anterior Segment Services, CL Gupta Eye Institute, Moradabad, Uttar Pradesh, India"},{"name":"The Bodhya Eye Consortium: a. Dr Shroff\u2019s Charity Eye Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharad Nivrutti","family":"Gomase","sequence":"additional","affiliation":[{"name":"Department of Cornea and Anterior Segment Services, MGM Eye Institute, Raipur, Chhattisgarh, India"},{"name":"The Bodhya Eye Consortium: a. Dr Shroff\u2019s Charity Eye Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manvi","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Cornea and Anterior Segment Services, Dr Shroff\u2019s Charity Eye Hospital, New Delhi, India"},{"name":"The Bodhya Eye Consortium: a. Dr Shroff\u2019s Charity Eye Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam Singh","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Cornea and Refractive Services, Sadguru Netra Chikitsalaya, Jankikund, Chitrakoot, Uttar Pradesh, India"},{"name":"The Bodhya Eye Consortium: a. Dr Shroff\u2019s Charity Eye Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atanu","family":"Majumdar","sequence":"additional","affiliation":[{"name":"Biostatistician, Dr Shroff\u2019s Charity Eye Hospital\/Sadguru Netra Chikitsalaya, India"},{"name":"The Bodhya Eye Consortium: a. Dr Shroff\u2019s Charity Eye Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Podder","sequence":"additional","affiliation":[{"name":"Biostatistician, Dr Shroff\u2019s Charity Eye Hospital\/Sadguru Netra Chikitsalaya, India"},{"name":"The Bodhya Eye Consortium: a. 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