{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:43:50Z","timestamp":1786653830596,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n                    Keratoconus eyes develop corneal decompensation more often compared to eyes with primary congenital glaucoma (PCG) following Descemet\u2019s membrane (DM) tear. This study was conducted to compare the posterior corneal morphology in areas with DM breaks with regards to DM and pre-Descemet\u2019s layer (PDL) between the two. In this cross-sectional comparative study, anterior segment optical coherence tomography (AS-OCT) scans of the posterior cornea of advanced keratoconus eyes with hydrops (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 12), PCG eyes with Haab\u2019s striae (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 15), and healthy control eyes (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 14) were compared for DM\u2013PDL morphology. These were further corroborated by the histopathology of corneal buttons from keratoconus (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 14) and PCG (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 13) cases obtained following penetrating keratoplasty and compared with controls (enucleated retinoblastoma globes, n = 6) on light microscopy and collagen IV immunostaining. AS-OCT showed a thicker median DM\/PDL complex in PCG (80 \u00b5m) versus keratoconus eyes (36 \u00b5m,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.01; Kruskal\u2013Wallis test). The median height and length of detached DM\u2013PDL were significantly more in keratoconus versus PCG (145 \u03bcm, 1766.1 \u00b1 1320.6 \u03bcm vs. 26.5 \u03bcm, 453.3 \u00b1 303.2 \u03bcm, respectively,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.012; Kruskal\u2013Wallis test). Type-1 DM\/PDL detachment (seen as a characteristic taut chord) in keratoconus (90%) was the most common morphological pattern versus intracameral twin protuberance (92%) following DM breaks in PCG. Histopathology confirmed thicker DM in PCG (median: 63.4 \u03bcm) versus keratoconus eyes (median: 33.2 \u00b5m) or controls (27.1 \u03bcm) (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.001; Kruskal\u2013Wallis test). Greater height\/length of DM\/PDL detachment compounded by poor healing response (lower DM\/PDL thickness) probably causes more frequent corneal decompensation in keratoconus eyes when compared to PCG eyes following DM tears.\n                  <\/jats:p>","DOI":"10.4103\/ijo.ijo_1527_23","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T01:00:20Z","timestamp":1707181220000},"page":"735-740","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative posterior corneal profile of keratoconus hydrops versus Haab\u2019s striae in congenital glaucoma"],"prefix":"10.4103","volume":"72","author":[{"given":"Sohini","family":"Mandal","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeewan S","family":"Titiyal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viney","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"R1-20260504","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0002-9394(98)00068-3","article-title":"Intrastromal clefts in keratoconus patients with hydrops","volume":"126","author":"Feder","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"R2-20260504","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ophtha.2014.07.029","article-title":"Corneal changes in childhood glaucoma","volume":"122","author":"Patil","year":"2015","journal-title":"Ophthalmology"},{"key":"R3-20260504","first-page":"187","article-title":"Acute hydrops in the corneal ectasias: Associated factors and outcomes","volume":"97","author":"Grewal","year":"1999","journal-title":"Trans Am Ophthalmol Soc"},{"key":"R4-20260504","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/ICO.0b013e318165b92d","article-title":"Corneal endothelial cell density and morphology after acute hydrops in keratoconus","volume":"27","author":"Alsuhaibani","year":"2008","journal-title":"Cornea"},{"key":"R5-20260504","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1177\/1120672119841190","article-title":"Cataract extraction in patients with primary congenital glaucoma","volume":"30","author":"Morales-Fern\u00e1ndez","year":"2020","journal-title":"Eur J Ophthalmol"},{"key":"R6-20260504","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ajo.2020.05.038","article-title":"\u201cDescemet Membrane Detachment\u201d: A novel concept in diagnosis and classification","volume":"218","author":"Dua","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"R7-20260504","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/ICO.0000000000002472","article-title":"The Descemet membrane in primary congenital glaucoma","volume":"40","author":"Gupta","year":"2021","journal-title":"Cornea"},{"key":"R8-20260504","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ajo.2019.03.017","article-title":"Are Descemet membrane ruptures the root cause of corneal hydrops in keratoconic eyes?","volume":"205","author":"Parker","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"R9-20260504","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/eye.2016.62","article-title":"Clinical evidence of the pre-Descemets layer (Dua\u2019s layer) in corneal pathology","volume":"30","author":"Dua","year":"2016","journal-title":"Eye (Lond)"},{"key":"R10-20260504","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1136\/bjophthalmol-2014-306287","article-title":"Efficacy and safety of pre-Descemet\u2019s membrane sutures for the management of acute corneal hydrops in keratoconus","volume":"99","author":"Yahia Ch\u00e9rif","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"R11-20260504","first-page":"1734","article-title":"Synchrotron x-ray diffraction studies of keratoconus corneal stroma","volume":"33","author":"Fullwood","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R12-20260504","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00003226-199403000-00003","article-title":"Increased gelatinolytic activity in keratoconus cultures. A correlation to an altered matrix metalloproteinase-2\/tissue inhibitor of metalloproteinase ratio","volume":"13","author":"Kenney","year":"1994","journal-title":"Cornea"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_1527_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:42:57Z","timestamp":1786650177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_1527_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,5]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_1527_23","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,5]]},"assertion":[{"value":"2023-06-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}