{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:38:01Z","timestamp":1793237881222,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To assess the role of oral bio-enhanced curcumin in dry eye disease (DED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Randomized, double-masked, placebo-controlled clinical study conducted at a tertiary eye center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty patients of bilateral mild to moderate DED were randomized in two groups \u2013 group A (topical carboxy methyl cellulose QID + oral placebo) and group B (topical carboxy methyl cellulose QID + oral bio-enhanced curcumin). The objective parameters of DED were quantified at baseline and compared at 3 months follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At three months follow-up, there was significant improvement in curcumin group in terms of Ocular Surface Disease Index (OSDI) score (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002), tear meniscus height (TMH) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002), tear volume (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.006), tear break-up time (TBUT) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), non-invasive break-up time (NIBUT) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.026), lipid layer thickness (LLT) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01), and decrease in bulbar redness (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002). There was no significant improvement in limbal redness (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.097), corneal-staining score (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.93), and Schirmer\u2019s test (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.42). Mild adverse drug reaction was observed in three cases of the curcumin group and one case of group A.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Oral bio-enhanced curcumin is a safe and effective treatment modality in cases of mild to moderate DED. It effectively improves the tear film stability, LLT, and TMH and reduces the bulbar redness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1572_24","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T12:00:06Z","timestamp":1744891206000},"page":"S428-S434","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Role of oral bio-enhanced curcumin in dry eye disease"],"prefix":"10.4103","volume":"73","author":[{"given":"Dikshit","family":"Kapil","sequence":"first","affiliation":[{"name":"Cornea, Cataract and Refractive Surgery, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aafreen","family":"Bari","sequence":"additional","affiliation":[{"name":"Cornea, Cataract and Refractive Surgery, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, Delhi, 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