{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:17:54Z","timestamp":1788164274807,"version":"build-2803163510"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the role of preoperative ultrasound biomicroscopy (UBM) in diagnosing invasive ocular surface squamous neoplasia (OSSN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective single institution-based study included surgical cases of OSSN, in which UBM was performed preoperatively. The UBM characteristics of OSSN and signs of invasion were studied. The preoperative UBM imaging findings were correlated with the postoperative histopathological examination (HPE). The performance of UBM was studied in predicting invasive OSSN, considering HPE as the gold standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Fifteen patients were included in the study, with an average age of 61 \u00b1 12.8 years and an 80% male preponderance (n = 12). A clear plane between the lesion and the sclera was considered as episcleral or \u2018non-invasive,\u2019 and disruption of this interface was interpreted as \u2018invasive OSSN.\u2019 Compared to postoperative HPE, UBM interpretation predicted invasive OSSN with an accuracy of 73.3%, a sensitivity of 71.4%, and 100% specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>UBM is a useful adjunctive tool for assessing the invasion, lesion height, and depth of invasion in OSSN. On correlating with HPE, UBM showed a good performance in preoperative detection of invasive OSSN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_158_26","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:00:18Z","timestamp":1788163218000},"page":"1384-1387","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Utility of ultrasound biomicroscopy in detecting invasive ocular surface squamous neoplasia"],"prefix":"10.4103","volume":"74","author":[{"given":"Obaidur","family":"Rehman","sequence":"first","affiliation":[{"name":"Department of Oculoplasty and Ocular Oncology, Dr. Shroff\u2019s Charity Eye Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swanubhuti","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Oculoplasty and Ocular Oncology, Dr. Shroff\u2019s Charity Eye Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Oculoplasty and Ocular Oncology, Dr. Shroff\u2019s Charity Eye Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"R1-20260831","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/ICU.0000000000000771","article-title":"The role of imaging technologies for ocular surface tumors","volume":"32","author":"Venkateswaran","year":"2021","journal-title":"Curr Opin Ophthalmol"},{"key":"R2-20260831","doi-asserted-by":"crossref","first-page":"5435092","DOI":"10.1155\/2016\/5435092","article-title":"Anterior segment imaging in ocular surface squamous neoplasia","volume":"2016","author":"Ong","year":"2016","journal-title":"J Ophthalmol"},{"key":"R3-20260831","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/eye.2011.11","article-title":"In vivo confocal microscopy of ocular surface squamous neoplasia","volume":"25","author":"Parrozzani","year":"2011","journal-title":"Eye (Lond)"},{"key":"R4-20260831","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/eye.2012.15","article-title":"The clinical value of in vivo confocal microscopy for diagnosis of ocular surface squamous neoplasia","volume":"26","author":"Xu","year":"2012","journal-title":"Eye (Lond)."},{"key":"R5-20260831","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1097\/ICO.0000000000001680","article-title":"High-resolution anterior segment optical coherence tomography in intraepithelial versus invasive ocular surface squamous neoplasia","volume":"37","author":"Singh","year":"2018","journal-title":"Cornea"},{"key":"R6-20260831","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000490251","article-title":"Ocular surface squamous neoplasia with intraocular extension: Clinical and ultrasound biomicroscopic findings","volume":"5","author":"Meel","year":"2019","journal-title":"Ocul Oncol Pathol"},{"key":"R7-20260831","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ajo.2019.05.017","article-title":"Use of high-resolution optical coherence tomography in the surgical management of ocular surface squamous neoplasia: A pilot study","volume":"206","author":"Karp","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"R8-20260831","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40662-019-0152-3","article-title":"Utility of high-resolution anterior segment optical coherence tomography in the diagnosis and management of sub-clinical ocular surface squamous neoplasia","volume":"6","author":"Tran","year":"2019","journal-title":"Eye Vis (Lond)"},{"key":"R9-20260831","doi-asserted-by":"crossref","first-page":"14221","DOI":"10.1038\/s41598-022-18545-6","article-title":"Topical pharmacotherapy for ocular surface squamous neoplasia: Systematic review and meta-analysis","volume":"12","author":"Kozma","year":"2022","journal-title":"Sci Rep"},{"key":"R10-20260831","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.32604\/or.2025.067221","article-title":"Topical chemotherapy for ocular surface squamous neoplasia: A review of adverse effects and their clinical management","volume":"33","author":"Corgiolu","year":"2025","journal-title":"Oncol Res"},{"key":"R11-20260831","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jtos.2022.12.002","article-title":"Topical 1% 5-fluorouracil eye drops as primary treatment for ocular surface squamous neoplasia: Long-term follow-up study","volume":"27","author":"Wylegala","year":"2023","journal-title":"Ocul Surf"},{"key":"R12-20260831","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1001\/archopht.1997.01100150810025","article-title":"Surgical management of conjunctival tumors. 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