{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:36:59Z","timestamp":1787071019181,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To assess the factors associated with malignant glaucoma (MG) following intraocular surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective case\u2013control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Institutional.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Population:<\/jats:title>\n                    <jats:p>A total of 40 eyes with MG and 80 controls were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 40 patients who developed malignant glaucoma following intraocular surgery between January 1995 and December 2013 were compared with 80 age- and gender-matched controls who underwent surgery during the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures:<\/jats:title>\n                    <jats:p>The associated factors for the development of malignant glaucoma following intraocular surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Diagnosis in cases included primary angle closure glaucoma (PACG: 31 [77.5%]), primary open-angle glaucoma (POAG: 2 [5%]), pseudoexfoliation glaucoma (PXFG: 4 [10%]); in controls included PACG 44 (55%) and POAG 36 (45%), (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Trabeculectomy was performed in 24 cases (50%) and 28 (35%) controls, phaco-trabeculectomy in 14 cases (35%) and 52 eyes (65%) in controls, and cataract surgery in 2 cases (5%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004). Factors associated on univariate analysis included PACG (odds ratio [OR]: 12.68, 95% confidence interval [CI]; 2.84, 56.62,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001, synechial angle closure &gt; 180\u00b0 (OR: 10.1, 95% CI: 2.87, 35.44,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001, higher preoperative IOP &gt; 22 mmHg (OR: 5.32, 95% CI: 2.64, 10.73,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), trabeculectomy (OR: 3.05, 95% CI: 1.36, 6.83,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007) and axial length &lt; 22 mm (OR: 6.80, 95% CI: 2.51, 18.46,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001. The use of postoperative cycloplegics was protective on univariate analysis (OR: 0.268, 95% CI: 0.12, 0.596),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Preoperative IOP &gt; 22 mmHg (2.85, 95% CI: 1.11, 7.31,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02), and trabeculectomy (OR: 4.09, 95% CI: 1.48, 11.3,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007) remained significant on multivariate analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>PACG eyes with higher preoperative IOP and eyes undergoing trabeculectomy surgery alone, increased the likelihood of developing MG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1609_24","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:09:24Z","timestamp":1740139764000},"page":"S240-S243","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Clinical associations for the development of malignant glaucoma following intraocular surgery"],"prefix":"10.4103","volume":"73","author":[{"given":"Shantha","family":"Balekudaru","sequence":"first","affiliation":[{"name":"Jadhavbhai Nathamal Singhvi Glaucoma Department, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Pandey","sequence":"additional","affiliation":[{"name":"Jadhavbhai Nathamal Singhvi Glaucoma Department, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parveen","family":"Rewri","sequence":"additional","affiliation":[{"name":"Jadhavbhai Nathamal Singhvi Glaucoma Department, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"George","sequence":"additional","affiliation":[{"name":"Jadhavbhai Nathamal Singhvi Glaucoma Department, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingam","family":"Vijaya","sequence":"additional","affiliation":[{"name":"Jadhavbhai Nathamal Singhvi Glaucoma Department, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani","family":"Baskaran","sequence":"additional","affiliation":[{"name":"Jadhavbhai Nathamal Singhvi Glaucoma Department, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"R1-20250221","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0039-6257(87)90101-9","article-title":"Malignant glaucoma","volume":"32","author":"Luntz","year":"1987","journal-title":"Surv Ophthalmol"},{"key":"R2-20250221","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/bjo.81.2.163","article-title":"Malignant glaucoma and its management","volume":"81","author":"Ruben","year":"1997","journal-title":"Br J Ophthalmol"},{"key":"R3-20250221","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3928\/15428877-20080301-03","article-title":"Hypotonous malignant glaucoma: Aqueous misdirection with low intraocular pressure","volume":"39","author":"Burgansky-Eliash","year":"2008","journal-title":"Ophthalmic Surg Lasers Imaging"},{"key":"R4-20250221","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0002-9394(51)91168-3","article-title":"Malignant glaucoma","volume":"34","author":"Chandler","year":"1951","journal-title":"Am J Ophthalmol"},{"key":"R5-20250221","first-page":"217","article-title":"Role of vitreous detachment in aphakic and malignant glaucoma","volume":"58","author":"Schaffer","year":"1954","journal-title":"Trans Am Acad Ophthamol Otolarygol"},{"key":"R6-20250221","first-page":"565","article-title":"Hydraulic flow conductivity of the vitreous gel","volume":"16","author":"Fatt","year":"1977","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R7-20250221","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00061198-200304000-00013","article-title":"Possible mechanisms of primary angle-closure and malignant glaucoma","volume":"12","author":"Quigley","year":"2003","journal-title":"J Glaucoma"},{"key":"R8-20250221","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/S0161-6420(94)31222-X","article-title":"Malignant glaucoma. 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