{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:58:16Z","timestamp":1785437896364,"version":"3.56.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>This consensus statement provides a practical, step-by-step framework designed by 19 national specialists to standardize the care of optic neuritis. Recognizing that clinicians handle these cases differently depending on local resources, the guidelines offer a clear roadmap for distinguishing true optic nerve inflammation from its common clinical mimics. The primary focus is on identifying early \u201cred flags,\u201d optimizing neuroimaging protocols, and using targeted cell-based antibody testing to pinpoint the exact cause of the disease. Beyond immediate diagnosis, the paper outlines clear strategies for managing acute episodes with high-dose therapies, handling patients who do not respond to initial steroids, and establishing structured, long-term monitoring plans to track visual recovery. 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