{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:41Z","timestamp":1786649741821,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Marfan syndrome (MFS) is a genetic disorder associated with considerable morbidity and mortality. Presently, well-documented information on this condition is not available in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this retrospective cohort study, we recruited patients with clinically diagnosed MFS who presented to the outpatient department using revised Ghent nosology. We retrieved complete ophthalmic information, including vision, anterior and posterior segments, exported from electronic medical records, and relevant investigations, surgical details, and follow-up data were obtained in a specific, pretested format.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Our cohort consisted of 86 eyes of 43 patients and had a male preponderance. The prevalence was 20.5 per 100,000 individuals. The mean age of the patients was 23.9 years. All eyes were treated either optically with refraction or surgically using lensectomy and vitrectomy with suture supported scleral fixated intraocular lens (IOL), which significantly affected the visual outcome (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although considered a rare disease, MFS is commonly found in the ophthalmological setting. Refraction and surgery (lensectomy with scleral fixated IOL) may improve the vision significantly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1651_21","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T07:51:02Z","timestamp":1644997862000},"page":"626-629","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Clinical profile and outcome of ocular manifestation in Marfans syndrome in India"],"prefix":"10.4103","volume":"70","author":[{"given":"Shreya","family":"Shah","sequence":"first","affiliation":[{"name":"Pediatric Ophthalmology, Drashti Netralaya, Dahod, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehul","family":"Shah","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology, Drashti Netralaya, Dahod, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Chandane","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology, Drashti Netralaya, Dahod, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakshi","family":"Makhloga","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology, Drashti Netralaya, Dahod, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeksha","family":"Thorat","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology, Drashti Netralaya, Dahod, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera","family":"Sanghani","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology, Drashti Netralaya, Dahod, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s13023-015-0369-8","article-title":"Prevalence, incidence, and age at diagnosis in Marfan syndrome","volume":"10","author":"Groth","year":"2015","journal-title":"Orphanet J Rare Dis"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41598-020-80755-7","article-title":"Clinically relevant variants in a large cohort of Indian patients with Marfan syndrome and related disorders identified by next-generation sequencing","volume":"11","author":"Nayak","year":"2021","journal-title":"Sci Rep"},{"key":"R3-20251006","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2147\/TACG.S60472","article-title":"Perspectives on the revised Ghent criteria for the diagnosis of Marfan syndrome","volume":"8","author":"von 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ectopia lentis in Marfan syndrome","author":"Erdogan","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"R22-20251006","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3390\/jcm9030721","article-title":"Classifying ectopia lentis in Marfan syndrome into five grades of increasing severity","volume":"9","author":"Zech","year":"2020","journal-title":"J Clin Med"},{"key":"R23-20251006","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/ceo.13596","article-title":"Visual outcome and surgical results in children with Marfan syndrome","volume":"47","author":"Rezar-Dreindl","year":"2019","journal-title":"Clin Exp Ophthalmol"},{"key":"R24-20251006","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s10792-020-01322-7","article-title":"Outcome of sutured scleral fixated intraocular lens in Marfan syndrome in pediatric eyes","volume":"40","author":"Sen","year":"2020","journal-title":"Int 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