{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:37:10Z","timestamp":1787071030590,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the incidence and severity of retinopathy of prematurity (ROP) amongst surviving triplets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Records of preterm babies born to mothers with triplet pregnancies were retrieved from our Indian twin city ROP study database between 1 Jan 2000 and 31 Dec 2020 and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>253 surviving triplet babies born to 108 mothers were evaluated. 48 out of 108 (44%) mothers received treatment for infertility. Data was available and analyzed for 242 babies (484 eyes). Mean gestational age was 31.76 \u00b1 3.74 weeks (26- 38 weeks). The mean birth weight was 1.44 \u00b1 0.37 kg (0.57\u20132.76 kg). At the first screening, incomplete vascularization was noted in 67% (131 babies;322 eyes) of which ROP was diagnosed in 14% (28 babies; 56 eyes). Among them, only 18 babies (53%) were the smallest birth weight babies in each of the triplet sets. Treatment with laser or bevacizumab was performed in 14 babies (5.8%), one eye of one baby additionally needed vitreoretinal surgical intervention. Good anatomical outcomes in terms of regression of ROP without sequelae were achieved in all babies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The present study reveals low incidence and favorable outcomes of ROP in triplet pregnancies in a large cohort of babies from a middle-income country. Our cohort did not show any difference in the treatment-requiring ROP among the larger or smaller birth weight babies of the same gestational age. In multiple pregnancies, gestational age remains a critical factor for ROP development; however, this does not necessitate modifying screening or treatment criteria in such triplet pregnancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1700_23","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T05:00:42Z","timestamp":1713243642000},"page":"1780-1785","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Retinopathy of prematurity in triplets \u2013 Indian twin city ROP study report number 12"],"prefix":"10.4103","volume":"72","author":[{"given":"Manjushree","family":"Bhate","sequence":"first","affiliation":[{"name":"Jasti V. Ramanamma Childrens\u2019 Eye Care Centre, Child Sight Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Srimati Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmaja Kumari","family":"Rani","sequence":"additional","affiliation":[{"name":"Srimati Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Belenje","sequence":"additional","affiliation":[{"name":"Srimati Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika C","family":"Parmeshwarappa","sequence":"additional","affiliation":[{"name":"Srimati Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhadra","family":"Jalali","sequence":"additional","affiliation":[{"name":"Jasti V. Ramanamma Childrens\u2019 Eye Care Centre, Child Sight Institute, Hyderabad, Telangana, India"},{"name":"Srimati Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"R1-20260425","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/112067210301300504","article-title":"Ophthalmologic follow-up of premature twins and triplets","volume":"13","author":"Tomazzoli","year":"2003","journal-title":"Eur J Ophthalmol"},{"key":"R2-20260425","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/eye.2011.208","article-title":"A co-twin study of the relative effect of birth weight and gestational age on retinopathy of prematurity","volume":"25","author":"Woo","year":"2011","journal-title":"Eye (Lond)"},{"key":"R3-20260425","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00417-019-04597-4","article-title":"Retinopathy of prematurity in discordant twins: Is the small twin at increased risk?","volume":"258","author":"Zloto","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R4-20260425","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4103\/0301-4738.62645","article-title":"Profile of asymmetrical retinopathy of prematurity in twins","volume":"58","author":"Azad","year":"2010","journal-title":"Indian J Ophthalmol"},{"key":"R5-20260425","article-title":"RBSK guidelines"},{"key":"R6-20260425","first-page":"89","article-title":"Programme planning and screening strategy in retinopathy of prematurity","volume":"51","author":"Jalali","year":"2003","journal-title":"Indian J Ophthalmol"},{"key":"R7-20260425","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ajo.2010.10.007","article-title":"Outcomes of a protocol-based management for zone 1 retinopathy of prematurity: The Indian Twin Cities ROP Screening Program report number 2","volume":"151","author":"Jalali","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"R8-20260425","doi-asserted-by":"crossref","first-page":"610","DOI":"10.4103\/0301-4738.118449","article-title":"Impact of the day-30 screening strategy on the disease presentation and outcome of retinopathy of prematurity. 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