{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:30:50Z","timestamp":1787772650957,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To describe the clinical spectrum and management of glaucoma in congenital aphakia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The demographics and clinical spectrum of eyes with congenital aphakia with and without glaucoma were compared, and management outcomes of congenital aphakia cases with glaucoma were studied retrospectively between April 2000 and June 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were a total of 168 eyes (84 subjects) with a diagnosis of congenital aphakia, of which 29 eyes of 18 subjects were diagnosed with glaucoma. Corneal opacity was the presenting complaint in 26\/29 eyes with glaucoma and 139\/139 eyes without glaucoma. The (interquartile range (IQR)) horizontal corneal diameter was 10.5mm (IQR, 9.0-12.5) and 8mm (IQR, 5-10) in eyes with and without glaucoma (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01), respectively. The median (IQR) axial length was 17.5mm (IQR, 13.5-19.5) and 15mm (IQR, 14-16) mm in eyes with and without glaucoma (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03), respectively. Nineteen eyes with glaucoma had adequate intraocular pressure (IOP) control with one medication. Three eyes underwent transscleral diode cyclophotocoagulation and maintained IOP without medications. Three eyes underwent trabeculectomy and trabeculotomy, trabeculectomy followed by penetrating keratoplasty, and trabeculectomy, respectively, of which two eyes became phthisical. At the last follow-up, the median (IQR) IOP was 14 mm Hg (IQR, 14-17) Hg. The median (IQR) follow-up duration was 4.53 months (IQR, 2.03- 48.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>One-fifth of the eyes with congenital aphakia had secondary developmental glaucoma. The corneal diameter and axial lengths were higher in the eyes with glaucoma compared to eyes without glaucoma. Medical management is the preferred short-term mode of IOP control. Transscleral cyclophotocoagulation may be preferred over surgical intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1782_21","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T08:01:36Z","timestamp":1645776096000},"page":"834-838","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Secondary developmental glaucoma in eyes with congenital aphakia"],"prefix":"10.4103","volume":"70","author":[{"given":"Swathi Vallabh","family":"Badakere","sequence":"first","affiliation":[{"name":"Ahalia Foundation Eye Hospital, Palakkad, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simranjeet","family":"Aulakh","sequence":"additional","affiliation":[{"name":"Jasti V Ramanamma Children\u2019s Eye Care Center, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya Sree Ramya","family":"Achanta","sequence":"additional","affiliation":[{"name":"Centre for Rare Eye Diseases and Ocular Genetics, Hyderabad, Telangana, India"},{"name":"The Cornea Institute, Hyderabad, Telangana, India"},{"name":"Jasti V Ramanamma Children\u2019s Eye Care Center, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghava","family":"Chary","sequence":"additional","affiliation":[{"name":"VST Glaucoma Center, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirisha","family":"Senthil","sequence":"additional","affiliation":[{"name":"Jasti V Ramanamma Children\u2019s Eye Care Center, Hyderabad, Telangana, India"},{"name":"VST Glaucoma Center, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Chaurasia","sequence":"additional","affiliation":[{"name":"Centre for Rare Eye Diseases and Ocular Genetics, Hyderabad, Telangana, India"},{"name":"The Cornea Institute, Hyderabad, Telangana, India"},{"name":"Jasti V Ramanamma Children\u2019s Eye Care Center, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muralidhar","family":"Ramappa","sequence":"additional","affiliation":[{"name":"Centre for Rare Eye Diseases and Ocular Genetics, Hyderabad, Telangana, India"},{"name":"The Cornea Institute, Hyderabad, Telangana, India"},{"name":"Jasti V Ramanamma Children\u2019s Eye Care Center, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak P","family":"Edward","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences and Pathology, University of Illinois Eye and Ear Infirmary, Chicago, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000429697","article-title":"Embryology of the eye and its adnexae","volume":"24","author":"Barishak","year":"1992","journal-title":"Dev Ophthalmol"},{"key":"B2-20240828","first-page":"1","article-title":"[Congenital primary aphakia from the genetic point of view]","volume":"154","author":"Manschot","year":"1969","journal-title":"Klin Monbl Augenheilkd"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4103\/0301-4738.53061","article-title":"Aniridia associated with congenital aphakia and secondary glaucoma","volume":"57","author":"Moreker","year":"2009","journal-title":"Indian J Ophthalmol"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.4103\/ijo.IJO_2078_19","article-title":"Anterior segment alterations in congenital primary aphakia-a clinicopathologic report of five cases","volume":"68","author":"Chaurasia","year":"2020","journal-title":"Indian J Ophthalmol"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1001\/archopht.1963.00960040577007","article-title":"Primary congenital aphakia","volume":"69","author":"Manschot","year":"1963","journal-title":"Arch Ophthalmol"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1475-1313.2006.00350.x","article-title":"The dazzle reflex:Electrophysiological signals from ocular muscles reveal strong binocular summation effects","volume":"26","author":"Plainis","year":"2006","journal-title":"Ophthalmic Physiol Opt"},{"key":"B7-20240828","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/sj.eye.6702840","article-title":"Congenital corneal opacities - 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