{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:43:53Z","timestamp":1786653833373,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"\n Purpose:<\/jats:title>\n To investigate 7-year changes in corneal densitometry (CD) and its influencing factors following small incision lenticule extraction (SMILE) for moderate to high myopia.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A total of 32 patients (52 eyes) with a mean spherical equivalent (SE) refraction of -6.30 \u00b1 1.30 D who underwent SMILE were recruited for this prospective study. Pre- and postoperative CD and corneal aberrations were measured by an oculus Pentacam system, and patients were followed up to 7 years. The CD evolution over time and its influencing factors were explored.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n No complications were observed after SMILE. There was a significant time effect on postoperative CD (\n P<\/jats:italic>\n < 0.05). The CD values at the 0-to-2 and 2-to-6 mm of the anterior layer increased at the first day (\n P<\/jats:italic>\n < 0.05) and declined to baselines at 1 year postoperatively; after that, CD values at any zone and any corneal layer presented a decreasing trend over time (all\n P<\/jats:italic>\n < 0.05). Multivariate analysis showed that postoperative CD was positively correlated with age and optical zone (OZ), whereas negatively correlated with SE, corrected distance visual acuity (CDVA), and corneal aberrations (higher-order aberrations, Coma0 and Coma90) (all\n P<\/jats:italic>\n < 0.05). Generalized estimating equation revealed that age, SE, CDVA, OZ, and Coma0 were the main factors influencing postoperative CD values (all\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n CD manifested a long-term decreasing trend in moderate to high myopia treated with SMILE. Its main influencing factors are age, SE, CDVA, OZ, and Coma0.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1787_23","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T01:00:35Z","timestamp":1707181235000},"page":"S429-S434","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Characterization the corneal transparency profile in SMILE-treated myopic patients with densitometry: A 7-year cohort study"],"prefix":"10.4103","volume":"72","author":[{"given":"Dongmei","family":"Yang","sequence":"first","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China"},{"name":"Second People's Hospital of Yunnan Province, Affiliated Hospital of Yunnan University, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuxiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China"},{"name":"Center for Optometry and Visual Science, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingtao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifang","family":"Wang","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Fudan University, Shanghai, China"},{"name":"Department of Nursing, Eye and ENT Hospital, Fudan University, Shanghai, China"},{"name":"NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China"},{"name":"Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"R1-20260504","first-page":"644","article-title":"Collagen fibrils in the human corneal stroma: Structure and aging","volume":"39","author":"Daxer","year":"1998","journal-title":"Invest Ophthalmol Vis 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