{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:35:49Z","timestamp":1787070949028,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the impact of scleral lenses (SLs) on higher-order aberrations (HOAs), corrected distance visual acuity (CDVA), and contrast sensitivity (CS) in pellucid marginal degeneration (PMD) eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>SLs were fitted in 24 eyes diagnosed with PMD. CDVA, CS, and HOAs were measured at baseline and with the lens on the eye. The HOAs were measured using an i-Trace aberrometer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A statistically significant improvement was noted in CDVA (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) with BSS lenses (0.05 \u00b1 0.04) compared to baseline (0.42 \u00b1 0.06). Front surface eccentricity 1 (FSE1) lens provided the best CDVA in most of the eyes. The baseline CS of 1.24 \u00b1 0.74 improved to 1.58 \u00b1 0.48 with SL and reported a statistically significant improvement (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and a gain of 6 letters. The baseline higher order-root mean square (HO-RMS) was 0.89 \u00b1 0.53 \u00b5m, which reduced to 0.38 \u00b1 0.24 \u00b5m (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and RMS coma of 0.45 \u00b1 0.29 \u00b5m improved to 0.20 \u00b1 0.12 \u00b5m (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Though there was a marginal reduction from 0.04 \u00b1 0.14 to 0.03 \u00b1 0.07, RMS spherical aberration did not show any statistically significant difference (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.37). RMS secondary astigmatism reduced from 0.17 \u00b1 0.15 \u00b5m to 0.08 \u00b1 0.12 \u00b5m (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007), and RMS trefoil reduced to 0.13 \u00b1 0.09 \u00b5m from 0.64 \u00b1 0.36 \u00b5m (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) with SLs and showed statistically significant improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SLs can be considered an effective option that corrects a significant amount of HOAs and enhances visual performances in PMD eyes.<\/jats:p>\n                  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