{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:05Z","timestamp":1786649705892,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the outcomes of lensectomy with a glued intraocular lens (IOL) in spherophakic eyes with secondary glaucoma and assess factors associated with failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We prospectively evaluated outcomes of lensectomy with glued IOL in 19 eyes with spherophakia and secondary glaucoma (intraocular pressure (IOP) \u226522 mm Hg and\/or glaucomatous optic disc damage) between 2016 and 2018. The vision, refractive error, IOP, antiglaucoma medications (AGMs), optic disc changes, need for glaucoma surgery, and complications were assessed. Success was defined as complete when IOP was \u22655 and \u226421 mmHg without AGMs; qualified success as similar IOP with up to 3 AGM; the need for &gt;3AGM\/additional surgery for IOP control was considered a failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Preoperatively, the median (interquartile range: IQR) age was 18 (13.5\u201330) years. IOP was 16 (14\u201322.5) mmHg on a median of 3 (2,3) AGMs. Median postoperative follow up was 27.7 months (11.9, 39.7). Postsurgery, most patients achieved emmetropia, with significantly decreased refractive error from a median spherical equivalent of \u221212.5D to + 0.5D,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0002. The complete success probability was 47% (95% confidence intervals (CIs): 29\u201376%) at 3 months and was 21% (8 \u2212 50%) at 1 year and 3 years. The qualified success probability was 93% (82\u2013100%) at 1 year, which reduced to 79% (60\u2013100%) in 3 years. None of the eyes had any retinal complications. The higher number of preoperative AGM was found to be a significant risk factor (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.02) for the failure of complete success.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>One-third of the eyes had IOP control without the need for AGM postlensectomy with glued IOL. Surgery resulted in significant improvement in visual acuity. The higher number of preoperative AGM was associated with poor glaucoma control after glued IOL surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1866_22","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T09:01:36Z","timestamp":1686733296000},"page":"2487-2492","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes of lensectomy with glued intraocular lens and factors associated with failure in eyes with spherophakia and glaucoma"],"prefix":"10.4103","volume":"71","author":[{"given":"Keerthi","family":"Burugupally","sequence":"first","affiliation":[{"name":"VST Glaucoma Center, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirisha","family":"Senthil","sequence":"additional","affiliation":[{"name":"VST Glaucoma Center, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika C","family":"Parameshwarappa","sequence":"additional","affiliation":[{"name":"Srimati Kanuri Santhamma Centre for Vitreo-Retinal Diseases, Kallam Anji Reddy Campus, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasnat","family":"Ali","sequence":"additional","affiliation":[{"name":"Center for Biostatistcs and Epidemiology, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Balakrishnan","sequence":"additional","affiliation":[{"name":"Giridhar Eye Institute, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrasekhar","family":"Garudadri","sequence":"additional","affiliation":[{"name":"VST Glaucoma Center, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1442-9071.1995.tb00160.x","article-title":"Ultrasound biomicroscopic features of spherophakia","volume":"23","author":"Macken","year":"1995","journal-title":"Aust N Z J Ophthalmol"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1444-0938.2002.tb03085.x","article-title":"Microspherophakia","volume":"85","author":"Chan","year":"2002","journal-title":"Clin Exp Optom"},{"key":"R3-20251006","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1097\/j.jcrs.0000000000000334","article-title":"Diagnosis and treatment of microspherophakia","volume":"46","author":"Yu","year":"2020","journal-title":"J Cataract Refract 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