{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:05Z","timestamp":1786649705473,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To study the corelation between outer retinal layer thickness (ORL), outer photoreceptor segment thickness (PROS), and central macular thickness (CMT) with best-corrected visual acuity (BCVA) in patients having clinically significant macular edema (CSME) and compare these parameters with normal patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a prospective, nonrandomized, observational, comparative study done during the period of January to May 2019. The study included 60 eyes of 36 patients. The patient population was segregated into two Groups: Group I (30 normal eyes of 15 normal patients) and Group II (30 eyes of 21 diabetic patients) with CSME. The comparison between ORL, PROS, and CMT was made between both the groups, and the correlation between ORL thickness, PROS thickness, and CMT with BCVA in Group II was studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age in Group I was 52.6+10.66 years, and 53.42+8.15 years in Group II. The male\/female ratio was 1.1:1 in Group I and 4:3 in Group II. The mean CMT was greater in Group II (330.13 \u00b1 37.01) than in Group I (222.20 \u00b1 12.30). The mean ORL thickness was greater in Group I (97.73 \u00b1 6.92) than in Group II (80.63 \u00b1 9.03). The PROS thickness was statistically significant in Group I (35.05 \u00b1 3.4) than in Group II (28.57 \u00b1 3.53). There was a strong correlation between BCVA and ORL thickness (r = \u22120.580,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and more strong correlation between BCVA and PROS thickness in Group II (r = \u22120.611,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.000). There was a moderate correlation between BCVA and CMT (r = 0.410,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.025), and all results were statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Both ORL and PROS thickness were greater in healthy normal eyes than in eyes with CSME. BCVA was strongly correlated with PROS and ORL thickness and moderately associated with CMT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1880_22","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T09:03:27Z","timestamp":1686733407000},"page":"2526-2530","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Correlation between different retinal layers with visual acuity in diabetic retinopathy patients with clinically significant macular edema"],"prefix":"10.4103","volume":"71","author":[{"given":"Shama","family":"Parveen","sequence":"first","affiliation":[{"name":"Senior Resident, Regional Institute of Ophthalmology, Department of Ophthalmology, BHU, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Mishra","sequence":"additional","affiliation":[{"name":"Senior Resident, Regional Institute of Ophthalmology, Department of Ophthalmology, BHU, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Gurnani","sequence":"additional","affiliation":[{"name":"Cornea, Cataract and Refactive Surgery, Sadguru Netra Chikitsalya, Chitrakoot, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirandeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Cornea, Paediatric Ophthalmology and Strabismus, Sadguru Netra Chikitsalya, Chitrakoot, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossameldin A","family":"Ziada","sequence":"additional","affiliation":[{"name":"Cornea and Refractive Unit, Al-Azhar University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanmay","family":"Srivastav","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Maa Vindhyavasini Autonomous State Medical College Mirzapur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Bhushan","sequence":"additional","affiliation":[{"name":"Senior Resident, Regional Institute of Ophthalmology, Department of Ophthalmology, BHU, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40662-015-0026-2","article-title":"Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss","volume":"2","author":"Lee","year":"2015","journal-title":"Eye Vis (Lond)"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/sj.eye.6703076","article-title":"Correlation between visual function and photoreceptor inner\/outer segment junction in patients with retinitis pigmentosa","volume":"23","author":"Aizawa","year":"2008","journal-title":"Eye"},{"key":"R3-20251006","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00417-009-1124-4","article-title":"Assessment of serous macular detachment in eyes with diabetic macular edema by use of spectral-domain optical coherence tomography","volume":"247","author":"Koleva-Georgieva","year":"2009","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R4-20251006","doi-asserted-by":"crossref","first-page":"920713","DOI":"10.1155\/2013\/920713","article-title":"Structural changes in individual retinal layers in diabetic macular edema","volume":"2013","author":"Murakami","year":"2013","journal-title":"J Diabetes Res"},{"key":"R5-20251006","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/ICU.0b013e3283524162","article-title":"The inner segment\/outer segment junction","volume":"23","author":"Wong","year":"2012","journal-title":"Curr Opin Ophthalmol"},{"key":"R6-20251006","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/IAE.0b013e3181bd2c5a","article-title":"Relationship between photoreceptor outer segment length and visual acuity in diabetic macular edema","volume":"30","author":"Forooghian","year":"2010","journal-title":"Retina"},{"key":"R7-20251006","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12886-019-1131-0","article-title":"Correlation of retinal layer changes with vision gain in diabetic macular edema during conbercept treatment","volume":"19","author":"Xu","year":"2019","journal-title":"BMC Ophthalmol"},{"key":"R8-20251006","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.4103\/ijo.IJO_1240_18","article-title":"Diabetic macular edema:Evidence-based management","volume":"66","author":"Browning","year":"2018","journal-title":"Indian J Ophthalmol"},{"key":"R9-20251006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","article-title":"Optical coherence tomography angiography","volume":"64","author":"Spaide","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"R10-20251006","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1167\/tvst.9.11.17","article-title":"Validation of an automated quantification of relative ellipsoid zone reflectivity on spectral domain-optical coherence tomography images","volume":"9","author":"Thiele","year":"2020","journal-title":"Transl Vis Sci Technol"},{"key":"R11-20251006","first-page":"8216150","article-title":"Quantitative assessment of outer retinal layer and photoreceptor outer segment layer and their relation to visual acuity in diabetic macular edema","volume":"2019","author":"AbdElhamid","year":"2019","journal-title":"J Ophthalmol"},{"key":"R12-20251006","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.sjopt.2016.12.006","article-title":"Thickness of the retinal photoreceptor outer segment layer in healthy volunteers and in patients with diabetes mellitus without retinopathy, diabetic retinopathy, or diabetic macular edema","volume":"31","author":"Ozkaya","year":"2017","journal-title":"Saudi J Ophthalmol"},{"key":"R13-20251006","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1038\/eye.2009.184","article-title":"Is neuronal dysfunction an early sign of diabetic retinopathy?Microperimetry and spectral domain optical coherence tomography (SD-OCT) study in individuals with diabetes, but no diabetic retinopathy","volume":"23","author":"Verma","year":"2009","journal-title":"Eye"},{"key":"R14-20251006","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/IAE.0000000000001599","article-title":"Outer retinal layer thickness as good visual predictor in patients with diabetic macular retina edema","volume":"38","author":"Eliwa","year":"2018","journal-title":"Retina"},{"key":"R15-20251006","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/j.ophtha.2010.03.051","article-title":"Relationship between optical coherence tomography retinal parameters and visual acuity in diabetic macular edema","volume":"117","author":"Alasil","year":"2010","journal-title":"Ophthalmology"},{"key":"R16-20251006","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10792-006-9007-8","article-title":"The correlation between optical coherence tomographic features and severity of retinopathy, macular thickness and visual acuity in diabetic macular edema","volume":"26","author":"Alkuraya","year":"2005","journal-title":"Int Ophthalmol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_1880_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:57:19Z","timestamp":1786647439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_1880_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_1880_22","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2022-07-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}