{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:28:38Z","timestamp":1792718918943,"version":"4.5.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      Dematiaceous fungi, the third most common causative organism of fungal keratitis, constitute 3.5% to 43.5% of fungal keratitis worldwide. Several studies on filamentous fungi (\n                      <jats:italic toggle=\"yes\">Aspergillus<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Fusarium<\/jats:italic>\n                      ) are available as opposed to that on dematiaceous fungal keratitis. This study aims to describe the profile of dematiaceous fungal keratitis in South India.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This institutional cohort study on culture-proven dematiaceous fungal keratitis was performed in a single ophthalmology referral center in South India for a 6-year period. Records were analyzed for demographic, clinical, microbiological, and treatment outcomes for 3 months from the date of presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      This study comprised 312 cases involving dematiaceous fungal keratitis (DFK). During the study period, DFK accounted for 10% of microbial keratitis and 24.6% of fungal keratitis cases. The mean (standard deviation) age was 54 (14) years. Males were commonly affected (73.4%). Keratitis was \u22641\/3\n                      <jats:sup>rd<\/jats:sup>\n                      depth in 47.8% of cases. Fifty-four cases (17.3%) demonstrated surface pigmentation, and 69 cases (22.1%) had endothelial plaque.\n                      <jats:italic toggle=\"yes\">Curvularia spp.<\/jats:italic>\n                      (99 eyes, 31.7%) was the most common fungal isolate among the speciated fungi. Topical medications resulted in the healing of 63.5% of cases. A total of 193 cases (79%) healed, and 49 cases had to undergo therapeutic penetrating keratoplasty (TPK). Early TPK was performed for 20 cases (40.8%). Seventeen eyes (34.6%) maintained clear grafts at the end of 3 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this extensive study on DFK, we report a high incidence of this group of fungal keratitis. We found an excellent healing rate in our cohort of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1881_23","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T05:02:10Z","timestamp":1716267730000},"page":"1721-1727","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Clinical, microbiologic, and treatment outcomes of dematiaceous fungal keratitis \u2013 A retrospective study"],"prefix":"10.4103","volume":"72","author":[{"given":"Niruban","family":"Ganesan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, JIPMER, Karaikal Campus, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivananda","family":"Narayana","sequence":"additional","affiliation":[{"name":"Department of Cornea Services, Aravind Eye Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Gubert","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Aravind Eye Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata K","family":"Bhosale","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Vinayaka Mission\u2019s Medical College, Vinayaka Missions\u2019s Research Foundation (Deemed to be University), Karaikal, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balagiri","family":"Sundar","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Aravind Eye Hospital, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"R1-20260425","first-page":"375","article-title":"Epidemiology of blindness in Nepal","volume":"63","author":"Brilliant","year":"1985","journal-title":"Bull World Health Organ"},{"key":"R2-20260425","first-page":"257","article-title":"Prevalence and causes of blindness in rural Bangladesh","volume":"82","author":"Khan","year":"1985","journal-title":"Indian J Med Res"},{"key":"R3-20260425","first-page":"214","article-title":"Corneal blindness: A global perspective","volume":"79","author":"Whitcher","year":"2001","journal-title":"Bull World Health Organ"},{"key":"R4-20260425","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/S1473-3099(20)30448-5","article-title":"The global incidence and diagnosis of fungal keratitis","volume":"21","author":"Brown","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"R5-20260425","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.ajo.2005.07.032","article-title":"Climatology of dematiaceous fungal keratitis","volume":"140","author":"Wilhelmus","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"R6-20260425","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/00003226-200208000-00004","article-title":"The epidemiological features and laboratory results of fungal keratitis: A 10-year review at a referral eye care center in South India","volume":"21","author":"Gopinathan","year":"2002","journal-title":"Cornea"},{"key":"R7-20260425","first-page":"315","article-title":"Epidemiological characteristics and laboratory diagnosis of fungal keratitis. 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