{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:58:30Z","timestamp":1787169510647,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To report outcomes and assess the risk factors for failure of trabeculectomy (trab), trabeculectomy with mitomycin-C (trabMMC), and combined trabeculectomy with cataract extraction (CT) in vernal keratoconjunctivitis (VKC) eyes with steroid-induced glaucoma (SIG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Trab was performed in 45 eyes of 30 subjects, trabMMC in 36 eyes of 25 subjects, and CT in 34 eyes of 27 subjects. Success was complete when intraocular pressure (IOP) was between 6 and 21 mm Hg without anti-glaucoma medications (AGM) and qualified with AGM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Median age (14 vs. 16.3 and 17.4 years) was significantly less in the trab cohort (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007). Majority (88%\u201393%) were male (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.78). Preoperatively, median duration of steroid usage was &gt;2 years (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.52), mean IOP (32, 29.4, and 28.4;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.26) and median cup:disc ratio (CDR) (0.9;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.27) were similar in the three groups. Complete success (76%, 71%, and 66% at 5 years;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.91), and qualified success (88%, 97%, and 94% at 5 years;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 1.0) with trab, trabMMC, and CT, respectively, were similar. Preoperative factors significantly associated with qualified failure (multiple logistic regression) were older children, longer duration of VKC, longer duration and mixed type of steroid use (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and larger CDR (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.02). At the last follow-up, 38% in trab, 33% in trabMMC, and 50% eyes in CT were blind (visual acuity \u226420\/400 and\/or visual field \u226410\u00b0) due to glaucoma (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.33).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The surgical success for all three types of surgery was similar at 5-years. Chronic VKC and long-term steroid use were associated with surgical failure. The majority had advanced disease and a significant proportion were blind due to glaucoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1897_21","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T08:01:36Z","timestamp":1645776096000},"page":"820-825","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Long-term outcomes and risk factors for failure of glaucoma filtering surgery in eyes with vernal keratoconjunctivitis and steroid-induced glaucoma"],"prefix":"10.4103","volume":"70","author":[{"given":"Sirisha","family":"Senthil","sequence":"first","affiliation":[{"name":"Glaucoma Department, VST Center for Glaucoma Care, L V Prasad Eye Institute, Banjara Hills, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha L","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, L 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