{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:34:39Z","timestamp":1786649679601,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>\n                    The objective of this meta-analysis was to evaluate the effect of prostaglandin analogues (PGA) on central corneal thickness (CCT) in patients with glaucoma. Key electronic databases were searched for randomized controlled trials (RCTs) involving the CCT effects of prostaglandin use for glaucoma. Primary outcome measures were the mean difference in the CCT measurement from baseline to the last available assessment. Intraocular pressure and other corneal changes were recorded as secondary. Efficacy estimates were measured by their weighted mean difference (WMD) with 95% confidence intervals (CI\u2019s) by using the random-effects model for primary and secondary outcomes Trial sequential analysis was used to determine if the current evidence was sufficient and conclusive. Eight RCTs met our inclusion criteria. A total of 879 patients were included. The overall effect showed that PGA\u2019s had a significant CCT lowering effect (WMD = \u22127.04, 95%CI: \u221210.07 to \u22124.00,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.00001). We pooled results of 5 RCT\u2019s on Travoprost (WMD = \u221210.44, 95%CI: \u221216.80 to \u22124.08,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.001), seven trials on Latanoprost (WMD = \u22124.73, 95% CI: \u22129.70 to 0.25,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.06), and three trials on Bimatoprost (WMD = \u221211.88, 95%CI: \u221221.03 to \u22122.73,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.01). The WMD across groups in &gt;6 months of PGA use was \u221211.37 (95%CI: \u221217.17 to \u22125.58,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.0001), and in &lt;6 months of PGAs group was \u22128.35 (95% CI: \u221212.01 to \u22124.69,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.00001), suggesting a longitudinal effect of PGAs on CCT. In conclusion, Bimatoprost and Travoprost caused a statistically significant reduction in the thickness of central cornea. Though only a few studies were included, the narrow confidence intervals and adequate sample size suggest that these findings are valid.\n                  <\/jats:p>","DOI":"10.4103\/ijo.ijo_1971_21","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T06:53:23Z","timestamp":1652252003000},"page":"1502-1512","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":21,"title":["Effect of prostaglandin analogues on central corneal thickness in patients with glaucoma: A systematic review and meta-analysis with trial sequential analysis"],"prefix":"10.4103","volume":"70","author":[{"given":"Rajani","family":"Kadri","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, A. J. Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akansha","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, A. J. Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devika","family":"Parameshwar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, A. J. Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay A","family":"Kudva","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, A. J. Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Achar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kanachur Institute of Medical Sciences, Mangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayaram","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, A. J. Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1089\/jop.2016.0036","article-title":"Change in central corneal thickness after the discontinuation of latanoprost in normal tension glaucoma-change in central corneal thickness after stop of latanoprost","volume":"33","author":"Yoo","year":"2017","journal-title":"J Ocul Pharmacol Ther"},{"key":"R2-20251006","first-page":"703","article-title":"Glaucoma","volume":"2011","author":"Shah","year":"2011","journal-title":"BMJ Clin Evid"},{"key":"R3-20251006","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1007\/s12325-020-01227-y","article-title":"Effects of netarsudil and latanoprost alone and in fixed combination on corneal endothelium and corneal thickness: Post-hoc analysis of 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History"}},{"value":"2021-11-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}