{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:20:54Z","timestamp":1787761254450,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"abstract":"\n Purpose:<\/jats:title>\n We sought to document the difference in the vitreoretinal configuration of Stage 4 retinopathy of prematurity (ROP) in photocoagulated and treatment naive eyes undergoing vitrectomy and to correlate it with surgical complexity.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Consecutive eyes posted for vitrectomy with Stage 4 ROP were documented preoperatively using a RetCam for the presence of peripheral traction (PT), presence of central traction just outside the arcades, and presence of traction extending to the lens. A note was made of the following intraoperative events: lensectomy, intraoperative bleeding, and iatrogenic breaks. Wilcoxon rank-sum test was used for analysis.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n From a total of 46 eyes, 16 and 30 eyes were from the treated and treatment naive group, respectively. More eyes in the treated group had central (\n P<\/jats:italic>\n < 0.0001) and lenticular traction (\n P<\/jats:italic>\n = 0.022). More eyes in the untreated group had PT (\n P<\/jats:italic>\n < 0.0001). A significant number of eyes without photocoagulation needed lensectomy (\n P<\/jats:italic>\n = 0.042), and no difference in intraoperative bleeding (\n P<\/jats:italic>\n = 0.94) was demonstrable. Iatrogenic retinotomy occurred in three eyes, all naive. Notably, age at surgery was more in the untreated group (\n P<\/jats:italic>\n = 0.00008).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Vasoproliferative activity in all retinopathies occurs at the junction of the ischemic and nonischemic retina. In the natural course of ROP, this takes place peripherally, at the ridge. In photocoagulated eyes, this junction is displaced posteriorly due to peripheral ablation. Treated eyes manifested with posterior proliferative changes and were more amenable to lens-sparing vitrectomy. Naive eyes were older when they underwent surgery to relieve PT with greater chances of lensectomy and iatrogenic breaks.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_1_17","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T23:17:01Z","timestamp":1505776621000},"page":"846-852","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Variation in the vitreoretinal configuration of Stage 4 retinopathy of prematurity in photocoagulated and treatment naive eyes undergoing vitrectomy"],"prefix":"10.4103","volume":"65","author":[{"given":"Salil Sharad","family":"Gadkari","sequence":"first","affiliation":[{"name":"Department of Vitreoretinal Surgery, PBMA's H V Desai Eye Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madan","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Department of Vitreoretinal Surgery, PBMA's H V Desai Eye Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"Pt 3","key":"R1-20251013","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/eye.1992.46","article-title":"Natural history of retinopathy of prematurity: A prospective study","volume":"6","author":"Fielder","year":"1992","journal-title":"Eye (Lond)"},{"key":"R2-20251013","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0161-6420(99)00003-2","article-title":"Telemedical evaluation and management of retinopathy of prematurity using a fiberoptic digital fundus camera","volume":"107","author":"Schwartz","year":"2000","journal-title":"Ophthalmology"},{"key":"R3-20251013","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1001\/archopht.1992.01080140140042","article-title":"Lens-sparing vitreoretinal surgery in infants","volume":"110","author":"Maguire","year":"1992","journal-title":"Arch Ophthalmol"},{"key":"R4-20251013","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/S0161-6420(01)00809-0","article-title":"Lens-sparing vitreous surgery for tractional stage 4A retinopathy of prematurity retinal detachments","volume":"108","author":"Capone","year":"2001","journal-title":"Ophthalmology"},{"key":"R5-20251013","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3341\/kjo.2006.20.2.113","article-title":"Lens-sparing vitrectomy for stage 4 and stage 5 retinopathy of prematurity","volume":"20","author":"Yu","year":"2006","journal-title":"Korean J Ophthalmol"},{"key":"R6-20251013","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1016\/j.ophtha.2004.05.030","article-title":"Lens-sparing vitrectomy for stage 4 retinopathy of prematurity","volume":"111","author":"Hubbard","year":"2004","journal-title":"Ophthalmology"},{"issue":"7 Suppl","key":"R7-20251013","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1097\/01.iae.0000244286.56133.09","article-title":"Fibrovascular organization in the vitreous following laser for ROP: Implications for prognosis","volume":"26","author":"Hartnett","year":"2006","journal-title":"Retina"},{"key":"R8-20251013","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S1350-9462(01)00012-X","article-title":"Development of the primate retinal vasculature","volume":"20","author":"Provis","year":"2001","journal-title":"Prog Retin Eye Res"},{"key":"R10-20251013","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000130069","article-title":"Retinopathy of prematurity: Clinic and pathogenesis. 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