{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:59Z","timestamp":1786649939791,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Settings:<\/jats:title>\n                    <jats:p>Identification of the prevalent species and report clinical features, predisposing factors, and visual outcomes of ocular infections caused by Scedosporium\/Lomentospora in a tertiary care eye centre North India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient\/Study Population:<\/jats:title>\n                    <jats:p>During a study period of 9 months from December 2022 to August 2023, eight cases of culture positive Scedosporium\/Lomentospora ocular infections diagnosed were included in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Observation Procedure:<\/jats:title>\n                    <jats:p>Definitive diagnosis was established on clinical suggestion of fungal infection along with microscopic findings and culture isolation of the fungal pathogen from clinical specimens. The main parameters assessed included predisposing (risk) factors, clinical characteristics, treatment modality used, and visual sequel of individual patients. Time to healing was stated as the time interval from beginning of clinical symptoms to the follow up visit when antifungals were stopped (absolute scarring of infiltrate).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome Measures:<\/jats:title>\n                    <jats:p>Of included eight cases, Scedosporium apiospermum was identified in five cases (including teleomorph state Pseudallescheria boydii and Graphium form) and Lomentospora prolificans was identified in three cases. The mean time to presentation at our hospital from the commencement of clinical disease was 19.2 days (range 1\u201330 day). History of trauma was present in five (83.3%) of six patients. Different clinical presentations predominantly included keratitis followed by endophthalmitis. Two cases (culture positive Lomentospora prolificans) with provisional diagnosis of fungal keratitis presented with complete corneal melt. Medical management alone with natamycin was successful in two cases, while other patients required surgical intervention in addition to medical management. Scleral involvement and vitreous involvement were associated with poor prognosis. The average time to healing in noted in our series was ~ 90 days. Thus, prompt diagnosis is critical for commencing targeted antifungal therapy as these fungi are resistant to many antifungal agents. Oral and topical antifungals along with surgical management (therapeutic penetrating keratoplasty) were successful for the treatment of S. apiospermum\/L. prolificans oculomycosis involving the posterior segment of the eye.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2019_24","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:00:36Z","timestamp":1758801636000},"page":"1471-1476","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Scedosporium apiospermum and Lomentospora prolificans emergent ocular infections in North India"],"prefix":"10.4103","volume":"73","author":[{"given":"Karnika","family":"Saigal","sequence":"first","affiliation":[{"name":"Section of Ocular Microbiology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishat H","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Section of Ocular Microbiology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Nandyala","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepanshi","family":"Mishra","sequence":"additional","affiliation":[{"name":"Section of Ocular Microbiology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murugesan","family":"Vanathi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika","family":"Tandon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridevi","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajpal S","family":"Vohra","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immaculata","family":"Xess","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeewan S","family":"Titiyal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/S1473-3099(20)30448-5","article-title":"The global incidence and diagnosis of fungal keratitis","volume":"21","author":"Brown","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jiph.2018.12.005","article-title":"Spectrum of mycotic keratitis in north India: Sixteen years study from a tertiary care ophthalmic centre","volume":"12","author":"Satpathy","year":"2019","journal-title":"J Infect Public Health"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3390\/jof7040273","article-title":"Mycotic Keratitis-A global threat from the filamentous fungi","volume":"7","author":"Hoffman","year":"2021","journal-title":"J Fungi (Basel)"},{"key":"R4-20260420","first-page":"1211","article-title":"Aetiology of suppurative corneal ulcers in Ghana and south India, and epidemiology of fungal keratitis. Br. J","volume":"86","author":"Leck","year":"2002","journal-title":"Ophthalmol"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1128\/CMR.00039-07","article-title":"Infections caused by Scedosporium spp","volume":"21","author":"Cortez","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"R6-20260420","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00003226-200207000-00016","article-title":"Fungal keratitis caused by Scedosporium apiospermum","volume":"21","author":"Wu","year":"2002","journal-title":"Cornea"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jcrs.2014.11.002","article-title":"Unusual case of Scedosporium apiospermum keratitis following phacoemulsification in a systemically well patient","volume":"41","author":"Jutley","year":"2015","journal-title":"J Cataract Refract Surg"},{"key":"R8-20260420","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4103\/ijo.IJO_524_17","article-title":"Ocular infections caused by Scedosporium apiospermum: A case series","volume":"66","author":"Ramakrishnan","year":"2018","journal-title":"Indian J Ophthalmol"},{"key":"R9-20260420","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1097\/ICO.0000000000000969","article-title":"Scedosporium keratitis: An experience from a tertiary eye hospital in South India","volume":"35","author":"Rathi","year":"2016","journal-title":"Cornea"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/13693780600752507","article-title":"Scedosporium apiospermum: Changing clinical spectrum of a therapy-refrac- tory opportunist","volume":"44","author":"Guarro","year":"2006","journal-title":"Med Mycol"},{"key":"R11-20260420","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/ICL.0b013e3181be722e","article-title":"Scedosporium scleritis or keratitis or both: Case series","volume":"35","author":"Jhanji","year":"2009","journal-title":"Eye Contact Lens"},{"key":"R12-20260420","first-page":"413953","article-title":"Refractory scedosporium apiospermum keratitis successfully treated with combination of amphotericin B and voriconazole","volume":"2013","author":"Fadzillah","year":"2013","journal-title":"Case Rep Ophthalmol Med"},{"key":"R13-20260420","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12348-021-00255-1","article-title":"Fungal keratitis caused by Pseudallescheria boydii: Clinical and mycological characteristics","volume":"11","author":"Izadi","year":"2021","journal-title":"J Ophthalmic Inflamm Infect"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_2019_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:00:12Z","timestamp":1786647612000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_2019_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,25]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_2019_24","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,25]]},"assertion":[{"value":"2024-08-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}