{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:19:48Z","timestamp":1787840388938,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2]]},"abstract":"\n Purpose:<\/jats:title>\n To assess the corneal parameters in rheumatoid arthritis (RA) patients.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We enrolled 64 patients with RA (32 receiving biologic and 32 receiving conventional drugs) and 32 healthy subjects. Keratometric values (anterior flat [K1], steep [K2], and mean keratometry [Km]), corneal thickness from the pupil center (CCT), apex (ACT), and the thinnest point (TCT), and corneal volume (CV) were measured and compared between the groups.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n K1, K2, and Km values were significantly higher in the RA group (P = 0.013,\n P<\/jats:italic>\n = 0.048,\n P<\/jats:italic>\n = 0.027, respectively). The means of CCT, ACT, TCT, and CV were significantly lower in RA patients (P < 0.001,\n P<\/jats:italic>\n < 0.001,\n P<\/jats:italic>\n < 0.001,\n P<\/jats:italic>\n = 0.011, respectively). When we divided RA patients into two groups according to the treatment and compared them to controls, the differences in K1, CCT, ACT, TCT and CV were significant (P = 0.030,\n P<\/jats:italic>\n = 0.005,\n P<\/jats:italic>\n = 0.001,\n P<\/jats:italic>\n = 0.001,\n P<\/jats:italic>\n = 0.034, respectively). K1 and CV values of RA-biologic group were similar to the control group (\n P<\/jats:italic>\n = 0.205 and\n P<\/jats:italic>\n = 0.127, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Biologic agents contribute to the improvement of K1 and CV values in patients with RA.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2024_22","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T03:00:40Z","timestamp":1706238040000},"page":"206-210","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of corneal parameters in patients with rheumatoid arthritis"],"prefix":"10.4103","volume":"72","author":[{"given":"Dilek","family":"\u00d6zkaya","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, S\u00fcleyman Demirel University Faculty of Medicine, Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atalay","family":"Do\u011fru","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, S\u00fcleyman Demirel University Faculty of Medicine, Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"Baykal","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, S\u00fcleyman Demirel University Faculty of Medicine, Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"R1-20260428","first-page":"62","article-title":"Occurrence of extraarticular disease manifestations is associated with excess mortality in a community-based cohort of patients with rheumatoid arthritis","volume":"29","author":"Turesson","year":"2002","journal-title":"J 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