{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:59:33Z","timestamp":1787169573845,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Animal models are useful in glaucoma research to study tissue response to wound healing. Smaller animals such as rats offer additional advantages in terms of availability of detection antibodies and microarrays with cheaper maintenance costs. In this study, we describe a glaucoma filtering surgery (GFS) model in adult Sprague\u2013Dawley rats by performing a sclerostomy using a 26-G needle and additionally placing a silicone tube (27 G) connecting the anterior chamber to the subconjunctival space to maintain a patent fistula for the flow of aqueous humor, thus providing a more definitive bleb. This technique will be useful in identifying and modifying newer targets in the wound healing process in order to improve surgical outcomes following GFS.<\/jats:p>","DOI":"10.4103\/ijo.ijo_2037_21","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T07:51:02Z","timestamp":1644997862000},"page":"662-664","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["A modified model of glaucoma filtering surgery in Sprague-Dawley rats"],"prefix":"10.4103","volume":"70","author":[{"given":"Surinder Singh","family":"Pandav","sequence":"first","affiliation":[{"name":"Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuri","family":"Akella","sequence":"additional","affiliation":[{"name":"Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Thattaruthody","sequence":"additional","affiliation":[{"name":"Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1001\/archopht.1986.01050240109050","article-title":"Wound healing after filtering surgery in owl monkeys","volume":"104","author":"Desjardins","year":"1986","journal-title":"Arch Ophthalmol"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"936","DOI":"10.2460\/ajvr.1995.56.07.936","article-title":"Effects, of topically applied mitomycin-C on intraocular pressure facility of outflow, and fibrosis after glaucoma filtration surgery in clinically normal dogs","volume":"56","author":"Glover","year":"1995","journal-title":"Am J Vet Res"},{"key":"R3-20251006","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1136\/bjo.82.9.1072","article-title":"New model of conjunctival scarring in the mouse eye","volume":"82","author":"Reichel","year":"1998","journal-title":"Br J Ophthalmol"},{"key":"R4-20251006","first-page":"1639","article-title":"Effect of varying the mitomycin-C treatment area in glaucoma filtration surgery in the rabbit","volume":"38","author":"Cordeiro","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R5-20251006","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1167\/iovs.04-0375","article-title":"Microarray analysis of the failure of filtering blebs in a rat model of glaucoma filtering surgery","volume":"45","author":"Esson","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R6-20251006","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3109\/02713689609000767","article-title":"Macrophages during fibrosis following scleral fistulising surgery in a rat model","volume":"15","author":"Sheridan","year":"1996","journal-title":"Curr Eye Res"},{"key":"R7-20251006","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/01.ijg.0000131482.86547.5a","article-title":"A new model of glaucoma filtering surgery in the rat","volume":"13","author":"Sherwood","year":"2004","journal-title":"J Glaucoma"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_2037_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:10:39Z","timestamp":1787166639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_2037_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,27]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_2037_21","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,27]]},"assertion":[{"value":"2021-08-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}