{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:16Z","timestamp":1786649896567,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To report the incidence, outcomes, and risk of surgical failure after early postoperative hypotony following Aurolab Aqueous Drainage Implant (AADI) surgery for adult and pediatric refractory glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Medical records of patients who underwent AADI between January 2013 and March 2017 with a minimum of 2-years follow-up were retrospectively reviewed. Early postoperative hypotony was defined as IOP \u22645 mmHg within the first 3 months after AADI. Surgical failure of AADI was defined as IOP &gt;21 mmHg or reduced &lt;20% below baseline on two consecutive follow-up visits after 3 months, IOP \u22645 mmHg on two consecutive follow-up visits after 3 months, reoperation for glaucoma or a complication, or loss of light perception vision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Early postoperative hypotony was seen in 15\/213 eyes (7%) in the adult group and in 6\/101 eyes (6%) in the pediatric group. The onset of hypotony was significantly earlier in the pediatric group (median = 39 days post AADI, IQR = 20\u201358 days) compared with adult eyes (median = 51 days post AADI, IQR = 30\u201372 days) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02). Eyes with early postoperative hypotony did not have an increased risk of cumulative surgical failure as compared with eyes without hypotony in both adult (33.3% vs. 23.7%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.48) and pediatric (33.3% vs. 13.7%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.16) refractory glaucoma. All eyes recovered from hypotony, though one adult eye developed retinal detachment and one pediatric eye developed corneal decompensation and lost vision.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early postoperative hypotony was an infrequent complication post AADI and occurred earlier in pediatric eyes. Early postoperative hypotony did not increase risk of surgical failure up to 2 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2076_22","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T09:22:50Z","timestamp":1675329770000},"page":"586-593","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Incidence, outcomes, and risk of surgical failure after development of early hypotony following Aurolab aqueous drainage implant surgery"],"prefix":"10.4103","volume":"71","author":[{"given":"Hiruni Kaushalya","family":"Wijesinghe","sequence":"first","affiliation":[{"name":"Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Varghese","family":"Puthuran","sequence":"additional","affiliation":[{"name":"Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeba","family":"Ishrath","sequence":"additional","affiliation":[{"name":"Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineela","family":"Patnam","sequence":"additional","affiliation":[{"name":"Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iswarya","family":"Mani","sequence":"additional","affiliation":[{"name":"Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subbaiah Ramasamy","family":"Krishnadas","sequence":"additional","affiliation":[{"name":"Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Jon","family":"Gedde","sequence":"additional","affiliation":[{"name":"Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.ophtha.2015.04.015","article-title":"Use of various glaucoma surgeries and procedures in medicare beneficiaries from 1994 to 2012","volume":"122","author":"Arora","year":"2015","journal-title":"Ophthalmology"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.ajo.2011.10.026","article-title":"Treatment outcomes in the Tube Versus Trabeculectomy (TVT) study after five years of follow-up","volume":"153","author":"Gedde","year":"2012","journal-title":"Am J 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