{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:21:37Z","timestamp":1787761297901,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>A 52-year-old woman presented with idiopathic active scleritis not responding to oral cyclophosphamide, azathioprine, and oral steroid. Her intraocular pressure in the left eye was 45 mm of Hg in spite of using combination of brinzolamide 1% and brimonidine 0.2% (thrice a day), timolol maleate 0.5% (twice a day) eye drops in both eyes and oral acetazolamide. She was administered subcutaneous golimumab 50 mg injection every 4 weeks along with oral methotrexate 15 mg\/week. The scleral inflammation responded and she underwent Ahmed glaucoma valve implantation after two months of initiation of golimumab therapy. After one week of surgery her IOP in left eye was the reduced to 8 mm of Hg. The index case showed that Golimumab can be a useful drug in the management of necrotizing scleritis refractory to the conventional therapy.<\/jats:p>","DOI":"10.4103\/ijo.ijo_2081_18","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T06:42:21Z","timestamp":1564123341000},"page":"1360-1362","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["A case of idiopathic necrotizing scleritis with secondary glaucoma treated successfully with golimumab and Ahmed valve implantation"],"prefix":"10.4103","volume":"67","author":[{"given":"Parthopratim","family":"Dutta Majumder","sequence":"first","affiliation":[{"name":"Department of Uvea, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Jayshree","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rathini Lilian","family":"David","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viswanath","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Apollo Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251013","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00417-012-2108-3","article-title":"Ocular hypertension and glaucoma incidence in patients with scleritis","volume":"251","author":"Heinz","year":"2013","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R2-20251013","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10792-013-9782-y","article-title":"Ahmed glaucoma valve surgery for necrotizing scleritis with secondary glaucoma","volume":"34","author":"Ranjan","year":"2014","journal-title":"Int Ophthalmol"},{"key":"R3-20251013","doi-asserted-by":"crossref","first-page":"444","DOI":"10.4103\/0301-4738.67043","article-title":"Management of bilateral idiopathic healed sclerokeratouveitis with ciliary and intercalary staphyloma with complicated cataract and secondary glaucoma","volume":"58","author":"Goel","year":"2010","journal-title":"Indian J Ophthalmol"},{"key":"R4-20251013","doi-asserted-by":"crossref","first-page":"1892.e3","DOI":"10.1016\/j.ophtha.2011.05.019","article-title":"Golimumab for uveitis","volume":"118","author":"Cordero-Coma","year":"2011","journal-title":"Ophthalmology"},{"key":"R5-20251013","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000060737","article-title":"Ocular hypertension and glaucoma associated with scleritis and uveitis. Aspects of epidemiology, pathogenesis and therapy","volume":"30","author":"Schlote","year":"1999","journal-title":"Dev Ophthalmol"},{"key":"R6-20251013","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0002-9394(81)90001-5","article-title":"Histopathologic and clinical associations of scleritis and glaucoma","volume":"91","author":"Wilhelmus","year":"1981","journal-title":"Am J Ophthalmol"},{"key":"R7-20251013","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s10792-015-0124-0","article-title":"Biologic therapy for refractory scleritis: A new treatment perspective","volume":"35","author":"de Fidelix","year":"2015","journal-title":"Int Ophthalmol"},{"key":"R8-20251013","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/09273948.2013.788724","article-title":"Rituximab therapy for refractory idiopathic scleritis","volume":"21","author":"Bogdanic-Werner","year":"2013","journal-title":"Ocul Immunol Inflamm"},{"key":"R9-20251013","first-page":"320","article-title":"Golimumab treatment for complicated uveitis","volume":"31","author":"Miserocchi","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"R10-20251013","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3109\/09273948.2013.844265","article-title":"Long-term treatment with golimumab for severe uveitis","volume":"22","author":"Miserocchi","year":"2014","journal-title":"Ocul Immunol Inflamm"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223307-201967080-00041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:31:09Z","timestamp":1787758269000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223307-201967080-00041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_2081_18","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"2018-12-29","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}