{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:23:41Z","timestamp":1787840621488,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"\n Purpose:<\/jats:title>\n To evaluate choroidal lesions with spectral domain optical coherence tomography (SD-OCT) scan in varicella zoster virus (VZV) uveitis.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n VZV-uveitis cases which underwent OCT scan for choroidal lesions were studied. SD-OCT scan passing through these lesions was studied in detail. Subfoveal choroidal thickness (SFCT) during active and resolved stages was studied. Angiogaphic features were studied where available.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Thirteen out of 15 cases had same-sided herpes zoster ophthalmicus skin rashes. All except three patients had old or active kerato-uveitis. All eyes demonstrated clear vitreous and a single or multiple hypopigmented orangish-yellow choroidal lesions. The number of lesions remained unchanged during the follow-up on clinical examination. SD-OCT over lesions (\n n<\/jats:italic>\n = 11) showed choroidal thinning (\n n<\/jats:italic>\n = 5), hyporeflective choroidal elevation during active inflammation (\n n<\/jats:italic>\n = 3), transmission effects (\n n<\/jats:italic>\n = 4), and ellipsoid zone disruption (\n n<\/jats:italic>\n = 7). The mean change in SFCT (\n n<\/jats:italic>\n = 9) after resolution of the inflammation was 26.3 \u03bcm (range: 3\u201390 \u03bcm). Fundus fluorescein angiography showed iso-fluorescence over lesions in all (\n n<\/jats:italic>\n = 5), but indocyanine green angiography (\n n<\/jats:italic>\n = 3) showed hypofluorescence at lesions. Mean follow-up was 1.38 years (range: 3 months\u20137 years). De-novo appearance of choroidal lesion during the first relapse of VZV-uveitis was captured in one case.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n VZV-uveitis can cause focal or multifocal hypopigmented choroidal lesions with thickening or scarring of choroidal tissue, depending on the disease activity.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2099_22","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T03:00:39Z","timestamp":1684292439000},"page":"1996-2000","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Choroidal lesions in varicella zoster virus uveitis"],"prefix":"10.4103","volume":"71","author":[{"given":"Ankush","family":"Kawali","sequence":"first","affiliation":[{"name":"Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aayesha","family":"Khanum","sequence":"additional","affiliation":[{"name":"Department of Retina, Narayana Nethralaya, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmamalini","family":"Mahendradas","sequence":"additional","affiliation":[{"name":"Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"Sanjay","sequence":"additional","affiliation":[{"name":"Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai-Bhakti","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Cornea and Refractive Surgery, Narayana Nethralaya, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/09273948.2017.1381272","article-title":"Clinical profile of herpes zoster ophthalmicus in a South Indian patient population","volume":"26","author":"Babu","year":"2018","journal-title":"Ocul Immunol Inflamm"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3126\/nepjoph.v3i2.5271","article-title":"Ocular manifestations in herpes zoster ophthalmicus","volume":"3","author":"Puri","year":"2011","journal-title":"Nepal J Ophthalmol"},{"key":"R3-20251006","first-page":"1","article-title":"Choroidal involvement in a 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chorioretinopathy","volume":"9","author":"Roberts","year":"1995","journal-title":"Eye"},{"key":"R7-20251006","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1080\/09273948.2020.1741649","article-title":"Viral kerato-uveitis with choroidal vitiligo","volume":"29","author":"Kawali","year":"2021","journal-title":"Ocul Immunol Inflamm"},{"key":"R8-20251006","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/IAE.0000000000000312","article-title":"Choroidal granulomas visualized by enhanced depth imaging optical coherence tomography","volume":"35","author":"Invernizzi","year":"2015","journal-title":"Retina"},{"key":"R9-20251006","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/0002-9394(86)90087-5","article-title":"A new fundus finding in patients with zoster ophthalmicus","volume":"102","author":"Amano","year":"1986","journal-title":"Am J Ophthalmol"},{"key":"R10-20251006","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1046\/j.1442-9071.2001.d01-30.x","article-title":"Multifocal chorioretinal atrophy associated with herpes zoster ophthalmicus","volume":"29","author":"McKelvie","year":"2001","journal-title":"Clin Exp Ophthalmol"},{"key":"R11-20251006","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1055\/s-0031-1273227","article-title":"Indocyanine green angiography findings in acute retinal necrosis syndrome","volume":"228","author":"Bissig","year":"2011","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"R12-20251006","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1016\/j.jcjo.2015.06.006","article-title":"Chorioretinitis with exudative retinal detachment secondary to varicella zoster virus","volume":"50","author":"Le","year":"2015","journal-title":"Can J Ophthalmol"},{"key":"R13-20251006","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1001\/jamaophthalmol.2022.4402","article-title":"Bilateral multifocal scleral nodules","volume":"140","author":"Shen","year":"2022","journal-title":"JAMA Ophthalmol"},{"key":"R14-20251006","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.ophtha.2020.04.018","article-title":"Focal scleral nodule: A new name for solitary idiopathic choroiditis and unifocal helioid choroiditis","volume":"127","author":"Fung","year":"2020","journal-title":"Ophthalmology"},{"key":"R15-20251006","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/S0161-6420(03)00580-3","article-title":"Nonnecrotizing herpetic retinopathies masquerading as severe posterior uveitis","volume":"110","author":"Bodaghi","year":"2003","journal-title":"Ophthalmology"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_2099_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:26:06Z","timestamp":1787837166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_2099_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_2099_22","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2022-08-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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