{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:51:49Z","timestamp":1790344309038,"version":"4.1.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To study the outcomes of femtosecond laser-assisted intrastromal negative meniscus lenticule implantation with accelerated corneal collagen crosslinking (FILAC) in advanced keratoconus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective, interventional study evaluated the outcomes of FILAC in eyes with progressive keratoconus of Amsler-Krumeich stage 4 with thinnest pachymetry of 320\u2013400 microns. A total of 10 eyes of 10 patients were enrolled. A negative meniscus allogenic stromal lenticule of 8.5 mm diameter was implanted into a corneal pocket created by a femtosecond laser at 150 microns depth and simultaneous accelerated corneal collagen crosslinking (CXL). Outcomes assessed 12 months after the procedure included uncorrected distance visual acuity (UDVA) and best-corrected visual acuity (BCVA), subjective refraction, and corneal topography changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean UDVA improved from baseline to 12 months follow-up (1.43 \u00b1 0.39 vs. 1.32 \u00b1 0.31 logMAR,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.49). Four patients did not accept contact lenses preoperatively, whereas all patients were successfully fitted with semi-scleral contact lenses postoperatively with a mean BCVA of 0.47 \u00b1 0.14 logMAR at 12 months. Mean corneal topographic values showed improvement from baseline to 12 months follow-up: K1 (58.44 \u00b1 5.59 to 55.57 \u00b1 5.68), K2 (63.35 \u00b1 6.86 to 59.35 \u00b1 7.1), Kmax (71.07 \u00b1 7.95 to 66.29 \u00b1 7.54) and astigmatism (4.89 \u00b1 3.35 to 3.88 \u00b1 2.35) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). The mean thinnest pachymetry improved significantly from baseline to 12 months follow-up (354.9 \u00b1 28.52 vs. 462.5 \u00b1 36.30 microns,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0001). There was a non-significant improvement in subjective refraction and aberrometry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This technique effectively halts disease progression and improves visual outcomes in advanced keratoconus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2139_24","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T07:00:09Z","timestamp":1744873209000},"page":"974-979","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Femtosecond laser-assisted corneal intrastromal negative meniscus lenticule implantation with accelerated collagen crosslinking (FILAC) in advanced keratoconus in Indian eyes: A prospective interventional study"],"prefix":"10.4103","volume":"73","author":[{"given":"Rajesh","family":"Sinha","sequence":"first","affiliation":[{"name":"Division of Cornea, Cataract and Refractive Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahnaz","family":"Anjum","sequence":"additional","affiliation":[{"name":"Division of Cornea, Cataract and Refractive Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartikeya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Cornea, Cataract and Refractive Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Division of Cornea, Cataract and Refractive Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Cornea, Cataract and Refractive Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridevi","family":"Nair","sequence":"additional","affiliation":[{"name":"Division of Cornea, Cataract and Refractive Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrishti","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Division of Cornea, Cataract and Refractive Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeewan S","family":"Titiyal","sequence":"additional","affiliation":[{"name":"Division of Cornea, Cataract and Refractive Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"R1-20260421","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","article-title":"Keratoconus","volume":"42","author":"Rabinowitz","year":"1998","journal-title":"Surv Ophthalmol"},{"key":"R2-20260421","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4103\/0974-9233.61213","article-title":"Corneal collagen cross-linking","volume":"17","author":"Jankov Ii","year":"2010","journal-title":"Middle East Afr J Ophthalmol"},{"key":"R3-20260421","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"Wollensak","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"R4-20260421","doi-asserted-by":"crossref","first-page":"619398","DOI":"10.1155\/2014\/619398","article-title":"Corneal collagen cross-linking with and without epithelial removal: A contralateral study with 0.5% hypotonic riboflavin solution","volume":"2014","author":"Stojanovic","year":"2014","journal-title":"Biomed Res Int"},{"key":"R5-20260421","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3928\/1081597X-20171004-04","article-title":"Femtosecond laser-assisted stromal lenticule addition keratoplasty for the treatment of advanced keratoconus: A preliminary study","volume":"34","author":"Mastropasqua","year":"2018","journal-title":"J Refract Surg"},{"key":"R6-20260421","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s10792-016-0349-6","article-title":"Corneal thickening and central flattening induced by femtosecond laser hyperopic-shaped intrastromal lenticule implantation","volume":"37","author":"Mastropasqua","year":"2017","journal-title":"Int Ophthalmol"},{"key":"R7-20260421","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1097\/ICO.0000000000000539","article-title":"Femtosecond intrastromal lenticular implantation combined with accelerated collagen cross-linking for the treatment of keratoconus\u2014Initial clinical result in 6 eyes","volume":"34","author":"Ganesh","year":"2015","journal-title":"Cornea"},{"key":"R8-20260421","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/ICO.0000000000001877","article-title":"Small-incision femtosecond laser-assisted intracorneal concave lenticule implantation in patients with keratoconus","volume":"38","author":"Jin","year":"2019","journal-title":"Cornea"},{"key":"R9-20260421","doi-asserted-by":"crossref","first-page":"786","DOI":"10.3928\/1081597X-20201005-01","article-title":"Customized stromal lenticule implantation for keratoconus","volume":"36","author":"Doroodgar","year":"2020","journal-title":"J Refract Surg"},{"key":"R10-20260421","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0039-6257(84)90094-8","article-title":"Keratoconus and related noninflammatory corneal thinning disorders","volume":"28","author":"Krachmer","year":"1984","journal-title":"Surv Ophthalmol"},{"key":"R11-20260421","first-page":"9","article-title":"Keratoconus treatment using femtosecond-assisted intrastromal corneal graft (FAISCG) surgery: A case series","volume":"11","author":"Jadidi","year":"2018","journal-title":"Int Med Case Rep J"},{"key":"R12-20260421","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3928\/1081597X-20180323-01","article-title":"Treatment of corneal ectasia by implantation of an allogenic corneal lenticule","volume":"34","author":"Li","year":"2018","journal-title":"J Refract Surg"},{"key":"R13-20260421","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jcro.2018.01.004","article-title":"Femtosecond laser-assisted intrastromal corneal lenticule implantation for treatment of advanced keratoconus in a child\u2019s eye","volume":"6","author":"Almodin","year":"2018","journal-title":"JCRS Online Case Rep"},{"key":"R14-20260421","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1167\/iovs.06-1285","article-title":"Magnitude and orientation of Zernike terms in patients with keratoconus","volume":"48","author":"Kosaki","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R15-20260421","first-page":"9","article-title":"Keratoconus treatment using femtosecond-assisted intrastromal corneal graft (FAISCG) surgery: a case series","volume":"11","author":"Jadidi","year":"2018","journal-title":"Int Med Case Rep J"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_2139_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:34:28Z","timestamp":1787067268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_2139_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_2139_24","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]},"assertion":[{"value":"2024-09-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}