{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:29:35Z","timestamp":1793730575373,"version":"4.6.1"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To describe clinical characteristics and treatment outcomes of children diagnosed with cavitary retinoblastoma (RB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective analysis of children treated for cavitary RB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 40 patients (43 eyes) with cavitary RB, 14 (35%) were female and 26 (65%) were male. At diagnosis, the average age was 25 months (median, 24 months; range 3\u201384 months). In 3 cases (8%), bilateral cavitary RB was seen. The most prevalent presenting symptoms were leukocoria (n = 21, 53%) and strabismus (n = 6, 15%) with a mean duration of symptoms of 23 weeks (median, 16 weeks; range 0\u2013104 weeks). As per the ICRB classification, 15 eyes (35%) were in group D, 12 eyes (28%) in group C, 10 eyes (23%) in group B, and 6 eyes (14%) in group E. Primary cavities, within the tumor, were seen in 14 eyes (33%), whereas secondary cavities were seen in 29 eyes (67%). Most of the eyes (n = 42, 98%) were treated with intravenous chemotherapy (IVC), and one eye (2%) received intra-arterial chemotherapy. In ten eyes (23%), the tumor recurred following IVC, and two cases exhibited a partial response to IVC. At the last follow-up (mean, 31 months), all eyes (100%) had local tumor control with no evidence of systemic metastasis or death. Regression of the cavities within the tumor was noted in 27 eyes (63%), while it remained stable in 16 eyes (37%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Cavitary RB (both primary and secondary) had a good initial response to standard chemotherapy with an overall excellent prognosis for globe salvage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2146_25","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T05:00:25Z","timestamp":1779858025000},"page":"876-881","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Cavitary retinoblastoma: Clinical features and treatment outcomes"],"prefix":"10.4103","volume":"74","author":[{"given":"Nakul","family":"Verma","sequence":"first","affiliation":[{"name":"Anant Bajaj Retina Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Anant Bajaj Retina Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijitha S","family":"Vempuluru","sequence":"additional","affiliation":[{"name":"The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Vijay Anand","family":"Reddy","sequence":"additional","affiliation":[{"name":"The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal R","family":"Raval","sequence":"additional","affiliation":[{"name":"Anant Bajaj Retina Institute, Hyderabad, Telangana, India"},{"name":"The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swathi","family":"Kaliki","sequence":"additional","affiliation":[{"name":"The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"R1-20261103","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1126\/science.6320372","article-title":"Retinoblastoma: Clues to human oncogenesis","volume":"223","author":"Murphree","year":"1984","journal-title":"Science"},{"key":"R2-20261103","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0031-3955(16)38079-8","article-title":"The genetics of retinoblastoma. 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